Tbio SPAG11B Sperm-associated antigen 11B

Protein Summary

Description

May have antimicrobial activity. May also play a role sperm maturation, storage, and protection. This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q08648
• E9PFH0
• Q546A0
• Q6ZYB2
• Q9H4P8
• Q9H4P9
• Q9H4Q0
• Q9H4Q1
• Q9H4Q2
• Q9NRT3
• Q9NRV4
• Q9NRV5
• Q9NRV6
• Q9NRV7
• Q9NRV8

Gene Name

• SPAG11B

Ensembl ID

• ENST00000297498
• ENSP00000297498
• ENSG00000164871
• ENST00000317900
• ENSP00000322591
• ENST00000398462
• ENSP00000381480
• ENST00000458665
• ENSP00000398550
• ENST00000528168
• ENSP00000431230
• ENST00000619134
• ENSP00000483205
• ENSG00000274405
• ENST00000622314
• ENSP00000481630

Symbol

• EP2
• HE2
• EP2
• HE2
• EP2C
• EP2D
• HE2C
• EDDM2B
• SPAG11
• SPAG11A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.98
cell line	0.6
cell type or tissue	0.57
disease perturbation	0.49
tissue	0.45

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.28   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 47   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.28   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0