You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SPAG1
Sperm-associated antigen 1

Protein Summary
Description
May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251809
  • ENSP00000251809
  • ENSG00000104450
  • ENST00000388798
  • ENSP00000373450
  • ENST00000520508
  • ENSP00000428070
  • ENST00000520643
  • ENSP00000427716

Symbol
  • SP75
  • TPIS
  • CT140
  • CILD28
  • HSD-3.8
  • HEL-S-268
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
protein domain
0.73
tissue sample
0.69
gene perturbation
0.66
cell line
0.55


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.31   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.31   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0