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Tbio
SPACA3
Sperm acrosome membrane-associated protein 3

Protein Summary
Description
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. The protein encoded by this gene is a sperm surface protein that may be involved in adhesion to the egg prior to fertilization. While the encoded protein has significant similarity to lysozyme at the amino acid level, it has no detectable bacteriocidal activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269053
  • ENSP00000269053
  • ENSG00000141316
  • ENST00000580599
  • ENSP00000463386

Symbol
  • LYC3
  • LYZL3
  • SLLP1
  • SPRASA
  • CT54
  • LYC3
  • LYZC
  • LYZL3
  • SLLP1
  • ALLP17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
protein domain
0.73
cellular component
0.67
biological process
0.55
cell line
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.1   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.1   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
FKBP14
Tbio
Family:  Enzyme
Novelty:  0.02742616
p_int:  0.997768495
p_ni:  0.002231485
p_wrong:  2e-8
Data Source:  BioPlex
AADAT
Tchem
Family:  Enzyme
Novelty:  0.00678753
p_int:  0.936986471
p_ni:  9e-9
p_wrong:  0.063013521
Score:  0.689
Data Source:  BioPlex,STRINGDB
FKBP7
Tbio
Family:  Enzyme
Novelty:  0.00572565
p_int:  0.894651379
p_ni:  0.105348621
Score:  0.197
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.881156767
p_ni:  0.118843233
Score:  0.275
Data Source:  BioPlex,STRINGDB
ANKRD46
Tbio
Novelty:  0.06546845
p_int:  0.801188412
p_ni:  0.166844874
p_wrong:  0.031966714
Score:  0.19
Data Source:  BioPlex,STRINGDB
SPACA4
Tdark
Novelty:  0.21569953
Score:  0.704
Data Source:  STRINGDB
SPACA1
Tbio
Novelty:  0.07415851
Score:  0.66
Data Source:  STRINGDB
ACRV1
Tbio
Novelty:  0.00291978
Score:  0.629
Data Source:  STRINGDB
ASTL
Tbio
Family:  Enzyme
Novelty:  0.02265035
Score:  0.603
Data Source:  STRINGDB
CCDC110
Tbio
Novelty:  0.11479518
Score:  0.573
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
82.8
refractive error measurement
3
2
3
8.6
71.4
Myopia
2
2
0
4.8
69.4
age at onset
1
1
0
8.6
17.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
82.8
refractive error measurement
3
8.6
71.4
Myopia
0
4.8
69.4
age at onset
0
8.6
17.2
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sperm acrosome associated 3
714491
Mouse
MGI:1922872
75622
Rat
RGD:1306684
287557
Dog
sperm acrosome associated 3
VGNC:46693
610702
Horse
sperm acrosome associated 3
VGNC:23471
100071732
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sperm acrosome associated 3
Mouse
Rat
Dog
sperm acrosome associated 3
Horse
sperm acrosome associated 3
Publication Statistics
PubMed Score 24.10
PubMed score by year
PubTator Score 9.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title