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Tbio
SPACA1
Sperm acrosome membrane-associated protein 1

Protein Summary
Description
Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for male fertility (PubMed:11870081). The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237201
  • ENSP00000237201
  • ENSG00000118434

Symbol
  • SAMP32
  • SAMP32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.76
cellular component
0.73
gene perturbation
0.56
PubMedID
0.48
tissue
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.59   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.59   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
KIAA1586
Tdark
Novelty:  2.30999532
p_int:  0.999969128
p_ni:  0.000030867
p_wrong:  6e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
DCP2
Tbio
Family:  Enzyme
Novelty:  0.00661786
p_int:  0.999648478
p_ni:  0.00035152
p_wrong:  2e-9
Data Source:  BioPlex
TATDN2
Tdark
Family:  Enzyme
Novelty:  1.40236433
p_int:  0.999060849
p_ni:  0.000655345
p_wrong:  0.000283807
Score:  0.189
Data Source:  BioPlex,STRINGDB
VPS13B
Tbio
Novelty:  0.02154769
p_int:  0.998832604
p_ni:  0.001167396
Data Source:  BioPlex
TYW1B
Tdark
Family:  Enzyme
Novelty:  0.86504466
p_int:  0.994932023
p_ni:  0.004853261
p_wrong:  0.000214716
Data Source:  BioPlex
MAP2K7
Tchem
Family:  Kinase
Novelty:  0.00916401
p_int:  0.993891135
p_ni:  0.006088535
p_wrong:  0.000020329
Score:  0.191
Data Source:  BioPlex,STRINGDB
TRO
Tbio
Novelty:  0.02850833
p_int:  0.992448531
p_ni:  0.007183905
p_wrong:  0.000367564
Data Source:  BioPlex
PLD1
Tchem
Family:  Enzyme
Novelty:  0.00608142
p_int:  0.991677124
p_ni:  0.008322875
p_wrong:  1e-9
Data Source:  BioPlex
DTWD1
Tdark
Novelty:  0.53044591
p_int:  0.990515403
p_ni:  0.005933522
p_wrong:  0.003551076
Score:  0.224
Data Source:  BioPlex,STRINGDB
C17orf80
Tbio
Novelty:  0.15267004
p_int:  0.983939162
p_ni:  0.016060838
Score:  0.226
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sperm acrosome associated 1
VGNC:3709
462877
Macaque
sperm acrosome associated 1
699611
Mouse
MGI:1914902
67652
Rat
RGD:1560284
500432
Dog
sperm acrosome associated 1
VGNC:46692
611635
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sperm acrosome associated 1
Macaque
sperm acrosome associated 1
Mouse
Rat
Dog
sperm acrosome associated 1
Publication Statistics
PubMed Score 14.59
PubMed score by year
PubTator Score 5.83
PubTator score by year
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Related Publications
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PMID
Year
Title