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Tbio
SPA17
Sperm surface protein Sp17

Protein Summary
Description
Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity). This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227135
  • ENSP00000227135
  • ENSG00000064199
  • ENST00000532692
  • ENSP00000432305

Symbol
  • SP17
  • CT22
  • SP17
  • SP17-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
gene perturbation
0.95
histone modification site profile
0.86
tissue sample
0.59
tissue
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.07   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.07   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
ROPN1L
Tbio
Novelty:  0.18077695
p_int:  0.999999932
p_ni:  6.6e-8
p_wrong:  2e-9
Score:  0.908
Data Source:  BioPlex,STRINGDB
EFCAB7
Tdark
Novelty:  0.36952617
p_int:  0.999999904
p_ni:  7e-8
p_wrong:  2.5e-8
Score:  0.827
Data Source:  BioPlex,STRINGDB
AKAP14
Tbio
Family:  Enzyme
Novelty:  0.50699923
p_int:  0.999999353
p_ni:  6e-9
p_wrong:  6.41e-7
Score:  0.896
Data Source:  BioPlex,STRINGDB
O43687
Tbio
Family:  Enzyme
Novelty:  0.04114095
p_int:  0.999998399
p_ni:  0.000001587
p_wrong:  1.4e-8
Score:  0.793
Data Source:  BioPlex,STRINGDB
FBXO44
Tbio
Novelty:  0.06669582
p_int:  0.999834918
p_ni:  0.000165077
p_wrong:  5e-9
Score:  0.309
Data Source:  BioPlex,STRINGDB
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  0.984893236
p_ni:  0.015106764
Score:  0.498
Data Source:  BioPlex,STRINGDB
MYL6B
Tbio
Novelty:  0.01292785
p_int:  0.824590436
p_ni:  0.175409564
Score:  0.544
Data Source:  BioPlex,STRINGDB
ROPN1
Tbio
Novelty:  0.05375245
Score:  0.937
Data Source:  STRINGDB
AKAP3
Tbio
Family:  Enzyme
Novelty:  0.030936
Score:  0.876
Data Source:  STRINGDB
SAGE1
Tdark
Novelty:  0.0080527
Score:  0.829
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
3
2
3
81.4
schizophrenia
8
2
2
1.1
79.9
serum metabolite measurement
1
1
1
78.7
1
1
0
1.1
59.9
self reported educational attainment
1
1
1
49.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
3
81.4
schizophrenia
2
1.1
79.9
serum metabolite measurement
1
78.7
0
1.1
59.9
self reported educational attainment
1
49.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sperm autoantigenic protein 17
VGNC:999
100608192
Macaque
sperm autoantigenic protein 17
574157
Mouse
MGI:1333778
20686
Rat
RGD:620154
85244
Dog
sperm autoantigenic protein 17
VGNC:46691
479402
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sperm autoantigenic protein 17
Macaque
sperm autoantigenic protein 17
Mouse
Rat
Dog
sperm autoantigenic protein 17
Publication Statistics
PubMed Score 46.07
PubMed score by year
PubTator Score 77.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title