You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SP4
Transcription factor Sp4

Protein Summary
Description
Binds to GT and GC boxes promoters elements. Probable transcriptional activator. The protein encoded by this gene is a transcription factor that can bind to the GC promoter region of a variety of genes, including those of the photoreceptor signal transduction system. The encoded protein binds to the same sites in promoter CpG islands as does the transcription factor SP1, although its expression is much more restricted compared to that of SP1. This gene may be involved in bipolar disorder and schizophrenia. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222584
  • ENSP00000222584
  • ENSG00000105866

Symbol
  • HF1B
  • SPR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.81
microRNA
0.75
histone modification site profile
0.71
phenotype
0.61
trait
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.99   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.99   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
VRK3
Tbio
Family:  Kinase
Novelty:  0.15665279
p_int:  0.999997454
p_ni:  0.000002406
p_wrong:  1.4e-7
Score:  0.411
Data Source:  BioPlex,STRINGDB
PTPRA
Tchem
Family:  Enzyme
Novelty:  0.01392344
p_int:  0.995154081
p_ni:  0.004845919
Score:  0.2
Data Source:  BioPlex,STRINGDB
HIRA
Tbio
Novelty:  0.01362595
p_int:  0.973204489
p_ni:  0.026568936
p_wrong:  0.000226576
Score:  0.34
Data Source:  BioPlex,STRINGDB
TMEM196
Tdark
Novelty:  0.37594264
Score:  0.724
Data Source:  STRINGDB
GJA5
Tbio
Novelty:  0.00195794
Score:  0.714
Data Source:  STRINGDB
MACC1
Tbio
Novelty:  0.00737376
Score:  0.665
Data Source:  STRINGDB
MMP28
Tbio
Family:  Enzyme
Novelty:  0.01679444
Score:  0.646
Data Source:  STRINGDB
HPS3
Tbio
Novelty:  0.03561482
Score:  0.624
Data Source:  STRINGDB
HPS5
Tbio
Novelty:  0.05155851
Score:  0.607
Data Source:  STRINGDB
ITGB8
Tbio
Novelty:  0.01564348
Score:  0.602
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
9
13
99.1
apolipoprotein B measurement
2
6
6
96.9
total cholesterol measurement
6
7
10
91.7
intelligence
2
5
2
6
68.2
1
1
0
1.2
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
13
99.1
apolipoprotein B measurement
6
96.9
total cholesterol measurement
10
91.7
intelligence
2
6
68.2
0
1.2
67.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sp4 transcription factor
VGNC:4514
472304
Macaque
Sp4 transcription factor
712174
Mouse
MGI:107595
20688
Rat
RGD:3741
25162
Dog
Sp4 transcription factor
VGNC:46687
482345
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sp4 transcription factor
Macaque
Sp4 transcription factor
Mouse
Rat
Dog
Sp4 transcription factor
Publication Statistics
PubMed Score 36.99
PubMed score by year
PubTator Score 127.08
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title