Tbio SP3 Transcription factor Sp3

Protein Summary

Description

Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• Q02447
• A0AVL9
• B4E2B7
• Q69B26
• Q69B27
• Q8TD56
• Q8WWU4
• Q9BQR1

Gene Name

• SP3

Ensembl ID

• ENST00000310015
• ENSP00000310301
• ENSG00000172845
• ENST00000640958
• ENSP00000492253

Symbol

• SPR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
transcription factor binding site profile	0.95
biological process	0.9
virus perturbation	0.88
hub protein	0.85

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Transcription Factor Sp3

Protein / Transcription Factor / Transcription Cofactor / Transcription Factor Sp3

Protein / Nucleic Acid Binding / Dna Binding Protein / Transcription Factor Sp3

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Transcription Factor Sp3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 792.23   (req: < 5)

Gene RIFs: 138   (req: <= 3)

Antibodies: 380   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 792.23   (req: >= 5)

Gene RIFs: 138   (req: > 3)

Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (74)

Explore Interacting Targets

1 – 10 of 74

• See Interactions on String-DB

SGCZ

Tbio

Novelty:  0.08511312

p_int:  0.999900626

p_ni:  0.000099356

p_wrong:  1.8e-8

Score:  0.297

Data Source:  BioPlex,STRINGDB

ADAM18

Tdark

Family:  Enzyme

Novelty:  0.22622379

p_int:  0.996562807

p_ni:  0.003317753

p_wrong:  0.000119441

Data Source:  BioPlex

PDGFRL

Tbio

Novelty:  0.0709225

p_int:  0.971842102

p_ni:  0.028109521

p_wrong:  0.000048376

Data Source:  BioPlex

TSHB

Tbio

Novelty:  0.00194403

p_int:  0.942704118

p_ni:  0.038813955

p_wrong:  0.018481928

Score:  0.381

Data Source:  BioPlex,STRINGDB

MBTPS1

Tchem

Family:  Enzyme

Novelty:  0.00845881

p_int:  0.862285858

p_ni:  0.137681606

p_wrong:  0.000032535

Data Source:  BioPlex

HDAC2

Tclin

Family:  Epigenetic

Novelty:  0.0011024

Score:  0.96

Data Source:  STRINGDB

SUMO1

Tbio

Novelty:  0.00137629

Score:  0.959

Data Source:  Reactome,STRINGDB

SP1

Tbio

Family:  TF

Novelty:  0.0007915

Score:  0.952

Data Source:  STRINGDB

CDKN1A

Tchem

Family:  Enzyme

Novelty:  0.00033009

Score:  0.952

Data Source:  STRINGDB

UBE2I

Tbio

Novelty:  0.00267883

Score:  0.951

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (13)

Reactome (5)

PathwayCommons (4)

WikiPathways (4)

Metabolism of proteins (R-HSA-392499)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592
Reactome	SUMO E3 ligases SUMOylate target proteins	170 targets	R-HSA-3108232
Reactome	SUMOylation	176 targets	R-HSA-2990846
Reactome	SUMOylation of transcription factors	21 targets	R-HSA-3232118

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational protein modification	1450 targets	R-HSA-597592
SUMO E3 ligases SUMOylate target proteins	170 targets	R-HSA-3108232
SUMOylation	176 targets	R-HSA-2990846
SUMOylation of transcription factors	21 targets	R-HSA-3232118

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (33)

Functions (7)

Components (5)

Processes (21)

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Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
RNA polymerase II regulatory region sequence-specific DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
proximal promoter sequence-specific DNA binding	Inferred from Sequence or structural Similarity (ISS)	ARUK-UCL
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
chromatin binding	Inferred from Electronic Annotation (IEA)	Ensembl
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Electronic Annotation (IEA)	Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
appendicular lean mass	EFO_0004980	1	1	1		68.3
red blood cell distribution width	EFO_0005192	2	1	2		42.3
multiple myeloma	EFO_0001378	1	1	0	1.1	27.3
BMI-adjusted waist circumference	EFO_0007789	1	1	1		24.5
mean corpuscular volume	EFO_0004526	1	1	1		17.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
appendicular lean mass	EFO_0004980	1		68.3
red blood cell distribution width	EFO_0005192	2		42.3
multiple myeloma	EFO_0001378	0	1.1	27.3
BMI-adjusted waist circumference	EFO_0007789	1		24.5
mean corpuscular volume	EFO_0004526	1		17.2

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Activator
Alternative initiation
Alternative splicing
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
appendicular lean mass
balding measurement
BMI-adjusted hip circumference
BMI-adjusted waist circumference
C-reactive protein measurement
mean corpuscular volume
mean reticulocyte volume
multiple myeloma
reaction time measurement
red blood cell density measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
craniofacial phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
limbs/digits/tail phenotype
liver/biliary system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	Sp3 transcription factor	VGNC:2817	459750
Macaque	Sp3 transcription factor		699901
Mouse	trans-acting transcription factor 3	MGI:1277166	20687
Rat	Sp3 transcription factor	RGD:1583765	367846
Dog	Sp3 transcription factor	VGNC:53107	488405

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Sp3 transcription factor
Macaque	Sp3 transcription factor
Mouse	trans-acting transcription factor 3
Rat	Sp3 transcription factor
Dog	Sp3 transcription factor

Publication Statistics

PubMed Score 792.23

PubMed score by year

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PubTator Score 790.74

PubTator score by year

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Related Publications

Text Mined References (174)

GeneRif Annotations (138)

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PMID	Year	Title