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Tbio
SOX9
Transcription factor SOX-9

Protein Summary
Description
Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development (PubMed:24038782). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (By similarity). The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245479
  • ENSP00000245479
  • ENSG00000125398
  • ENST00000645356
  • ENSP00000495527

Symbol
  • CMD1
  • SRA1
  • CMPD1
  • SRXX2
  • SRXY10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
PubMedID
0.99
small molecule perturbation
0.94
gene perturbation
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2375.77   (req: < 5)
Gene RIFs: 308   (req: <= 3)
Antibodies: 795   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2375.77   (req: >= 5)
Gene RIFs: 308   (req: > 3)
Antibodies: 795   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 131
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (401)
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.987
Data Source:  STRINGDB
RUNX2
Tbio
Family:  TF
Novelty:  0.00028804
Score:  0.964
Data Source:  Reactome,STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.96
Data Source:  STRINGDB
COL2A1
Tbio
Novelty:  0.0011102
Score:  0.943
Data Source:  STRINGDB
SHH
Tchem
Novelty:  0.00028347
Score:  0.938
Data Source:  STRINGDB
AMH
Tbio
Novelty:  0.00022501
Score:  0.911
Data Source:  STRINGDB
COL10A1
Tbio
Novelty:  0.00521991
Score:  0.904
Data Source:  STRINGDB
PRKG2
Tchem
Family:  Kinase
Novelty:  0.0138455
Score:  0.898
Data Source:  STRINGDB
NR5A1
Tchem
Family:  NR
Novelty:  0.00126037
Score:  0.891
Data Source:  STRINGDB
FOXL2
Tbio
Family:  TF
Novelty:  0.00224046
Score:  0.888
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Deactivation of the beta-catenin transactivating complex
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Signal Transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (135)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
nose morphology measurement
2
3
7
83.6
serum alanine aminotransferase measurement
2
2
1
7.1
76.2
serum gamma-glutamyl transferase measurement
2
3
2
2.4
68.3
hormone measurement
1
1
1
56.2
Varicose veins
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
nose morphology measurement
7
83.6
serum alanine aminotransferase measurement
1
7.1
76.2
serum gamma-glutamyl transferase measurement
2
2.4
68.3
hormone measurement
1
56.2
Varicose veins
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SRY-box 9
VGNC:51737
450101
Macaque
SRY-box 9
574208
Mouse
MGI:98371
20682
Rat
RGD:620474
140586
Dog
SRY-box 9
VGNC:46684
403464
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SRY-box 9
Macaque
SRY-box 9
Mouse
Rat
Dog
SRY-box 9
Publication Statistics
PubMed Score 2375.77
PubMed score by year
PubTator Score 1091.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title