Tbio SOX6 Transcription factor SOX-6

Protein Summary

Description

Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation. This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• P35712
• Q86VX7
• Q9BXQ3
• Q9BXQ4
• Q9BXQ5
• Q9H0I8

Gene Name

• SOX6

Ensembl ID

• ENST00000316399
• ENSP00000324948
• ENSG00000110693
• ENST00000396356
• ENSP00000379644
• ENST00000527619
• ENSP00000434455
• ENST00000528252
• ENSP00000432134
• ENST00000528429
• ENSP00000433233

Symbol

• SOXD
• HSSOX6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
biological process	0.9
disease	0.72
PubMedID	0.72
transcription factor	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.32   (req: < 5)

Gene RIFs: 65   (req: <= 3)

Antibodies: 244   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.32   (req: >= 5)

Gene RIFs: 65   (req: > 3)

Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0