You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SOX18
Transcription factor SOX-18

Protein Summary
Description
Binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site. This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340356
  • ENSP00000341815
  • ENSG00000203883

Symbol
  • HLTS
  • HLTRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.9
molecular function
0.84
PubMedID
0.77
tissue sample
0.71
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.08   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.08   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
PROX1
Tbio
Family:  TF
Novelty:  0.00349114
Score:  0.833
Data Source:  STRINGDB
FLT4
Tclin
Family:  Kinase
Novelty:  0.001296
Score:  0.831
Data Source:  STRINGDB
NR2F2
Tchem
Family:  NR
Novelty:  0.00450561
Score:  0.823
Data Source:  STRINGDB
LYVE1
Tbio
Novelty:  0.00186825
Score:  0.808
Data Source:  STRINGDB
VEGFC
Tbio
Novelty:  0.00077508
Score:  0.796
Data Source:  STRINGDB
MEF2C
Tbio
Family:  TF
Novelty:  0.00232724
Score:  0.748
Data Source:  STRINGDB
MMP7
Tchem
Family:  Enzyme
Novelty:  0.00080093
Score:  0.735
Data Source:  STRINGDB
FOXC2
Tbio
Family:  TF
Novelty:  0.00438844
Score:  0.709
Data Source:  STRINGDB
VEGFD
Tbio
Novelty:  0.00233128
Score:  0.703
Data Source:  STRINGDB
CCBE1
Tbio
Novelty:  0.03290164
Score:  0.68
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (45)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
7
12
95.7
triglyceride measurement
12
3
12
94.6
low density lipoprotein cholesterol measurement
7
2
7
92.3
systolic blood pressure
2
2
2
91.6
diastolic blood pressure
2
2
2
83.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
95.7
triglyceride measurement
12
94.6
low density lipoprotein cholesterol measurement
7
92.3
systolic blood pressure
2
91.6
diastolic blood pressure
2
83.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SRY-box 18
VGNC:6269
470008
Mouse
MGI:103559
20672
Rat
RGD:1311718
311723
Dog
SRY-box 18
VGNC:46677
485984
Cow
SRY-box 18
VGNC:35145
519439
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SRY-box 18
Mouse
Rat
Dog
SRY-box 18
Cow
SRY-box 18
Publication Statistics
PubMed Score 105.08
PubMed score by year
PubTator Score 52.47
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title