SOX17
Transcription factor SOX-17
Protein Summary
Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells (By similarity). This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 324.27 (req: < 5)
Gene RIFs: 59 (req: <= 3)
Antibodies: 401 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 324.27 (req: >= 5)
Gene RIFs: 59 (req: > 3)
Antibodies: 401 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 55
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (155)
Nearest Tclin Targets
Pathways (11)
Reactome (4)
KEGG (1)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Deactivation of the beta-catenin transactivating complex | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by WNT | ||||
Reactome | TCF dependent signaling in response to WNT | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Deactivation of the beta-catenin transactivating complex | ||||
Signal Transduction | ||||
Signaling by WNT | ||||
TCF dependent signaling in response to WNT | ||||
Viral Interactions (0)
Gene Ontology Terms (59)
Functions (9)
Components (4)
Processes (46)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 6 | 3 | 9 | 89.1 | |||||
serum gamma-glutamyl transferase measurement | 2 | 2 | 2 | 88.8 | |||||
myeloid white cell count | 2 | 2 | 2 | 85.1 | |||||
total cholesterol measurement | 4 | 2 | 7 | 81.6 | |||||
4 | 4 | 2 | 1.4 | 79.3 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 9 | 89.1 | |||||
serum gamma-glutamyl transferase measurement | 2 | 88.8 | |||||
myeloid white cell count | 2 | 85.1 | |||||
total cholesterol measurement | 7 | 81.6 | |||||
2 | 1.4 | 79.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | SRY-box 17 | VGNC:1161 | 740572 | |||||
Mouse | MGI:107543 | 20671 | ||||||
Rat | RGD:1305371 | 312936 | ||||||
Dog | SRY-box 17 | VGNC:46676 | 486955 | |||||
Cow | SRY-box 17 | VGNC:35144 | 534010 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | SRY-box 17 | |||||
Mouse | ||||||
Rat | ||||||
Dog | SRY-box 17 | |||||
Cow | SRY-box 17 | |||||
Publication Statistics
PubMed Score 324.27
PubMed score by year
PubTator Score 125.99
PubTator score by year
Related Publications
Text Mined References (72)
GeneRif Annotations (59)
Items per page:
0 of 0
PMID | Year | Title |
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