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Tbio
SOX10
Transcription factor SOX-10

Protein Summary
Description
Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 20 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360880
  • ENSP00000354130
  • ENSG00000100146
  • ENST00000396884
  • ENSP00000380093

Symbol
  • DOM
  • WS4
  • PCWH
  • WS2E
  • WS4C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
biological process
0.93
phenotype
0.81
biological term
0.78
gene perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 853.98   (req: < 5)
Gene RIFs: 127   (req: <= 3)
Antibodies: 859   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 853.98   (req: >= 5)
Gene RIFs: 127   (req: > 3)
Antibodies: 859   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (234)
PAX3
Tbio
Family:  TF
Novelty:  0.00140464
Score:  0.938
Data Source:  STRINGDB
OLIG2
Tbio
Family:  TF
Novelty:  0.0015221
Score:  0.937
Data Source:  STRINGDB
FOXD3
Tbio
Family:  TF
Novelty:  0.00550321
Score:  0.931
Data Source:  STRINGDB
MITF
Tchem
Family:  TF
Novelty:  0.00094044
Score:  0.914
Data Source:  STRINGDB
EGR2
Tbio
Family:  TF
Novelty:  0.00215433
Score:  0.88
Data Source:  STRINGDB
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
Score:  0.864
Data Source:  STRINGDB
DCT
Tbio
Family:  Enzyme
Novelty:  0.00411451
Score:  0.86
Data Source:  STRINGDB
PHOX2B
Tbio
Family:  TF
Novelty:  0.00227975
Score:  0.828
Data Source:  STRINGDB
SNAI2
Tbio
Family:  TF
Novelty:  0.00096495
Score:  0.827
Data Source:  STRINGDB
MPZ
Tbio
Novelty:  0.00223212
Score:  0.807
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Neural Crest Differentiation
WikiPathways
Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS
Name
Explore in Pharos
Explore in Source
Neural Crest Differentiation
Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (43)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
67.1
red blood cell distribution width
1
1
1
55.2
2
1
0
1.1
49.5
smoking status measurement
2
1
2
46.9
atrophic macular degeneration
1
1
0
1.1
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
67.1
red blood cell distribution width
1
55.2
0
1.1
49.5
smoking status measurement
2
46.9
atrophic macular degeneration
0
1.1
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SRY-box 10
VGNC:12928
470206
Mouse
MGI:98358
20665
Rat
RGD:3735
29361
Dog
SRY-box 10
VGNC:46672
481258
Horse
SRY-box 10
VGNC:23457
100054980
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SRY-box 10
Mouse
Rat
Dog
SRY-box 10
Horse
SRY-box 10
Publication Statistics
PubMed Score 853.98
PubMed score by year
PubTator Score 328.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title