Tdark SOWAHB Ankyrin repeat domain-containing protein SOWAHB

Protein Summary

Uniprot Accession IDs

• A6NEL2
• B2RP29

Gene Name

• SOWAHB

Ensembl ID

• ENST00000334306
• ENSP00000334879
• ENSG00000186212

Symbol

• ANKRD56
• ANKRD56

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.75
histone modification site profile	0.74
PubMedID	0.56
cell type or tissue	0.47
gene perturbation	0.47

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.13   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.13   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (23)

Explore Interacting Targets

1 – 10 of 23

• See Interactions on String-DB

TJP1

Tbio

Novelty:  0.00040365

p_int:  0.99999884

p_ni:  0.00000116

Data Source:  BioPlex

DIAPH2

Tbio

Novelty:  0.02008076

p_int:  0.999998714

p_ni:  0.000001072

p_wrong:  2.14e-7

Data Source:  BioPlex

DIAPH1

Tbio

Novelty:  0.0150259

p_int:  0.999994206

p_ni:  0.000005794

Data Source:  BioPlex

PLEKHA7

Tbio

Novelty:  0.05239328

p_int:  0.999793586

p_ni:  0.000206299

p_wrong:  1.15e-7

Data Source:  BioPlex

RAPGEF6

Tbio

Novelty:  0.07979293

p_int:  0.992200695

p_ni:  0.005222923

p_wrong:  0.002576382

Data Source:  BioPlex

PDZD11

Tbio

Novelty:  0.09750858

p_int:  0.959864666

p_ni:  0.00149432

p_wrong:  0.038641013

Data Source:  BioPlex

HSPA8

Tchem

Novelty:  0.00081014

p_int:  0.864621887

p_ni:  0.135378113

Data Source:  BioPlex

TJP2

Tbio

Novelty:  0.00446681

p_int:  0.861046947

p_ni:  0.138951998

p_wrong:  0.000001055

Data Source:  BioPlex

FAM189A1

Tdark

Novelty:  0.94298311

Score:  0.759

Data Source:  STRINGDB

SHROOM3

Tbio

Novelty:  0.02763602

Score:  0.738

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (0)

No GO Terms found

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2	2	2		86.6
emphysema pattern measurement	EFO_0005850	1	1	1		1.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2		86.6
emphysema pattern measurement	EFO_0005850	1		1.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
ANK repeat
Complete proteome
Phosphoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
emphysema pattern measurement
heel bone mineral density

MGI Phenotype Find Similar Targets

No Header	No Header
embryo phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	sosondowah ankyrin repeat domain family member B		699245
Mouse	sosondowah ankyrin repeat domain family member B	MGI:1925338	78088
Rat	sosondowah ankyrin repeat domain family member B	RGD:1311994	289501
Dog	sosondowah ankyrin repeat domain family member B	VGNC:46670	487815
Cow	sosondowah ankyrin repeat domain family member B	VGNC:35138	512359

Species	Name	OMA	EggNOG	Inparanoid
Macaque	sosondowah ankyrin repeat domain family member B
Mouse	sosondowah ankyrin repeat domain family member B
Rat	sosondowah ankyrin repeat domain family member B
Dog	sosondowah ankyrin repeat domain family member B
Cow	sosondowah ankyrin repeat domain family member B

Publication Statistics

PubMed Score 1.13

PubMed score by year

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PubTator Score 0.67

PubTator score by year

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Related Publications

Text Mined References (7)

Items per page:

10

0 of 0

PMID	Year	Title