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Tclin
SOST
Sclerostin

Protein Summary
Description
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301691
  • ENSP00000301691
  • ENSG00000167941

Symbol
  • CDD
  • VBCH
  • DAND6
  • SOST1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.92
biological process
0.66
microRNA
0.62
transcription factor
0.62
phenotype
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1347.47   (req: < 5)
Gene RIFs: 230   (req: <= 3)
Antibodies: 505   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1347.47   (req: >= 5)
Gene RIFs: 230   (req: > 3)
Antibodies: 505   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (135)
LRP6
Tbio
Novelty:  0.00305615
p_int:  0.999955988
p_ni:  0.000044012
Score:  0.991
Data Source:  BioPlex,Reactome,STRINGDB
CSH2
Tbio
Novelty:  0.0009706
p_int:  0.999809456
p_ni:  0.000190544
Score:  0.187
Data Source:  BioPlex,STRINGDB
LRP5
Tbio
Novelty:  0.00089807
p_int:  0.999754372
p_ni:  0.000245628
Score:  0.995
Data Source:  BioPlex,STRINGDB
SPOP
Tbio
Novelty:  0.00663363
p_int:  0.999651631
p_ni:  0.000348365
p_wrong:  4e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
SRRT
Tbio
Novelty:  0.00429818
p_int:  0.999561049
p_ni:  0.000438951
Data Source:  BioPlex
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
p_int:  0.993145885
p_ni:  0.006854115
Score:  0.285
Data Source:  BioPlex,STRINGDB
GTF2I
Tbio
Family:  TF
Novelty:  0.00703345
p_int:  0.991539435
p_ni:  0.008460565
Score:  0.195
Data Source:  BioPlex,STRINGDB
PSMG2
Tbio
Novelty:  0.11082503
p_int:  0.987815457
p_ni:  0.012184541
p_wrong:  2e-9
Data Source:  BioPlex
DCAF5
Tdark
Novelty:  0.39565074
p_int:  0.971741069
p_ni:  0.02825893
Data Source:  BioPlex
HERC2
Tbio
Family:  Enzyme
Novelty:  0.06552683
p_int:  0.971281535
p_ni:  0.028718465
Data Source:  BioPlex
Pathways (11)
Negative regulation of TCF-dependent signaling by WNT ligand antagonists (R-HSA-3772470)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
8
6
11
99
high density lipoprotein cholesterol measurement
7
5
12
98.8
heel bone mineral density
3
5
13
98.4
apolipoprotein A 1 measurement
2
2
2
95.5
bone density
4
6
7
89.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
11
99
high density lipoprotein cholesterol measurement
12
98.8
heel bone mineral density
13
98.4
apolipoprotein A 1 measurement
2
95.5
bone density
7
89.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sclerostin
VGNC:9642
740261
Mouse
MGI:1921749
74499
Rat
RGD:69358
80722
Dog
sclerostin
VGNC:46667
490948
Horse
sclerostin [Source:HGNC Symbol;Acc:HGNC:13771]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sclerostin
Mouse
Rat
Dog
sclerostin
Horse
sclerostin [Source:HGNC Symbol;Acc:HGNC:13771]
Publication Statistics
PubMed Score 1347.47
PubMed score by year
PubTator Score 418.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title