Tbio SORL1 Sortilin-related receptor

Protein Summary

Description

Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization. This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q92673
• B2RNX7
• Q92856

Gene Name

• SORL1

Ensembl ID

• ENST00000260197
• ENSP00000260197
• ENSG00000137642

Symbol

• C11orf32
• LR11
• LRP9
• SORLA
• gp250
• SorLA-1
• C11orf32

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
kinase perturbation	0.99
gene perturbation	0.97
protein domain	0.97
PubMedID	0.94

Protein Classes

PANTHER Classes

Protein / Transporter / Sortilin-related Receptor

Protein / Receptor / Sortilin-related Receptor

DTO Classes

Protein / Transporter / Sortilin-related Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 345.14   (req: < 5)

Gene RIFs: 173   (req: <= 3)

Antibodies: 221   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 345.14   (req: >= 5)

Gene RIFs: 173   (req: > 3)

Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0