Pharos : Target Details

Tdark

Protein Summary

Uniprot Accession IDs

Q5TF21

Gene Name

SOGA3

Ensembl ID

ENST00000525778
ENSP00000434570
ENSG00000214338

Symbol

C6orf174
C6orf174
dJ403A15.3

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.64

PubMedID	0.59

tissue sample	0.48

protein complex	0.43

cell line	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.34 (req: < 5)

View Publications

Gene RIFs: 0 (req: <= 3)

Antibodies: 42 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.34 (req: >= 5)

Gene RIFs: 0 (req: > 3)

Antibodies: 42 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (32)

Explore Interacting Targets

1 – 10 of 32

See Interactions on String-DB

SCN3B

Tbio

Family: IC

Novelty: 0.0438123

p_int: 0.999999973

p_ni: 2.1e-8

p_wrong: 7e-9

Score: 0.184

Data Source: BioPlex,STRINGDB

NRBF2

Tbio

Novelty: 0.02432243

p_int: 0.999997169

p_ni: 0.00000283

p_wrong: 1e-9

Score: 0.516

Data Source: BioPlex,STRINGDB

PPP2R1A

Tbio

Family: Enzyme

Novelty: 0.01134139

p_int: 0.999985537

p_ni: 0.000014459

p_wrong: 4e-9

Data Source: BioPlex

REEP5

Tbio

Novelty: 0.00160455

p_int: 0.999874381

p_ni: 0.00012554

p_wrong: 7.9e-8

Score: 0.192

Data Source: BioPlex,STRINGDB

MCOLN2

Tchem

Family: IC

Novelty: 0.05195244

p_int: 0.999608838

p_ni: 0.000389038

p_wrong: 0.000002124

Data Source: BioPlex

HS2ST1

Tbio

Family: Enzyme

Novelty: 0.04520207

p_int: 0.99397663

p_ni: 0.004888158

p_wrong: 0.001135212

Score: 0.187

Data Source: BioPlex,STRINGDB

ZNF214

Tbio

Family: TF

Novelty: 0.15323721

p_int: 0.993007275

p_ni: 0.002690449

p_wrong: 0.004302276

Score: 0.187

Data Source: BioPlex,STRINGDB

ZNF276

Tdark

Family: TF

Novelty: 0.3082638

p_int: 0.983995627

p_ni: 0.000890002

p_wrong: 0.015114371

Data Source: BioPlex

RGPD1

Tdark

Novelty: 3.43695158

Score: 0.693

Data Source: STRINGDB

MMACHC

Tbio

Novelty: 0.00896291

Score: 0.692

Data Source: STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Components (2)

Processes (1)

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Items per page:

1 – 2 of 2

GO Term	Evidence	Assigned by
extracellular space	Inferred from Electronic Annotation (IEA)	InterPro

integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (9)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
BMI-adjusted waist-hip ratio	EFO_0007788	5	6	9	89.5

waist-hip ratio	EFO_0004343	1	5	5	84.9

body mass index	EFO_0004340	1	1	1	62.1

heel bone mineral density	EFO_0009270	2	2	2	61.8

self reported educational attainment	EFO_0004784	1	1	1	51.4

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
BMI-adjusted waist-hip ratio	EFO_0007788	9	89.5

waist-hip ratio	EFO_0004343	5	84.9

body mass index	EFO_0004340	1	62.1

heel bone mineral density	EFO_0009270	2	61.8

self reported educational attainment	EFO_0004784	1	51.4

Beta Count

Odds Ratio

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UniProt Keyword

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No Header	No Header
Coiled coil

Complete proteome

Membrane

Phosphoprotein

Reference proteome

Signal

Transmembrane

Transmembrane helix

GWAS Trait

Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference

BMI-adjusted waist-hip ratio

body mass index

heel bone mineral density

hip circumference

mathematical ability

mean reticulocyte volume

self reported educational attainment

waist-hip ratio

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID
Chimp	SOGA family member 3		101058631

Macaque	SOGA family member 3		715731

Mouse	SOGA family member 3	MGI:1914662	67412

Rat	SOGA family member 3	RGD:11479453	108349256

Dog	SOGA family member 3		484118

Species	Name	OMA	EggNOG	Inparanoid
Chimp	SOGA family member 3

Macaque	SOGA family member 3

Mouse	SOGA family member 3

Rat	SOGA family member 3

Dog	SOGA family member 3

Publication Statistics

PubMed Score 0.34

PubMed score by year

PubTator Score 0.14

PubTator score by year

Related Publications

Text Mined References (3)

Items per page:

0 of 0

PMID	Year	Title