Tbio SOD3 Extracellular superoxide dismutase [Cu-Zn]

Protein Summary

Description

Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P08294
• Q5U781
• Q6FHA2
• EC-SOD

Gene Name

• SOD3

Ensembl ID

• ENST00000382120
• ENSP00000371554
• ENSG00000109610

Symbol

• EC-SOD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.83
disease perturbation	0.83
disease	0.74
molecular function	0.67
chemical	0.6

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Extracellular Superoxide Dismutase [Cu-zn]

DTO Classes

Protein / Enzyme / Oxidoreductase / Extracellular Superoxide Dismutase [Cu-zn]

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 781.31   (req: < 5)

Gene RIFs: 151   (req: <= 3)

Antibodies: 518   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 781.31   (req: >= 5)

Gene RIFs: 151   (req: > 3)

Antibodies: 518   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0