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Tbio
SOCS7
Suppressor of cytokine signaling 7

Protein Summary
Description
Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000612932
  • ENSP00000482229
  • ENSG00000274211
  • ENST00000615473
  • ENSP00000480736
  • ENSG00000274229

Symbol
  • NAP4
  • SOCS6
  • NAP4
  • NCKAP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.72
hub protein
0.71
transcription factor binding site profile
0.69
histone modification site profile
0.62
cellular component
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.63   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.63   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.999999999
Score:  0.837
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.999976181
p_ni:  1e-9
p_wrong:  0.000023818
Score:  0.478
Data Source:  BioPlex,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
Score:  0.957
Data Source:  STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.933
Data Source:  STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.905
Data Source:  STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.9
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.899
Data Source:  STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.897
Data Source:  STRINGDB
IRS1
Tchem
Novelty:  0.00048281
Score:  0.883
Data Source:  STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.845
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
JAK2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
JAK1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
TYK2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
JAK3
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
67.5
red blood cell distribution width
2
2
2
67.5
leukocyte count
1
1
1
59
leukocyte count
1
1
1
59
monocyte count
1
1
1
56
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
67.5
red blood cell distribution width
2
67.5
leukocyte count
1
59
leukocyte count
1
59
monocyte count
1
56
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2651588
192157
Rat
RGD:1307720
287659
Horse
suppressor of cytokine signaling 7
VGNC:23441
100069069
Cow
suppressor of cytokine signaling 7
VGNC:35125
540586
Pig
suppressor of cytokine signaling 7
100514187
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
suppressor of cytokine signaling 7
Cow
suppressor of cytokine signaling 7
Pig
suppressor of cytokine signaling 7
Publication Statistics
PubMed Score 71.63
PubMed score by year
PubTator Score 33.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title