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Tbio
SOCS3
Suppressor of cytokine signaling 3

Protein Summary
Description
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI fam ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330871
  • ENSP00000330341
  • ENSG00000184557

Symbol
  • CIS3
  • SSI3
  • CIS3
  • SSI3
  • ATOD4
  • Cish3
  • SSI-3
  • SOCS-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
virus perturbation
0.99
gene perturbation
0.98
disease perturbation
0.97
transcription factor binding site profile
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1051.56   (req: < 5)
Gene RIFs: 359   (req: <= 3)
Antibodies: 705   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1051.56   (req: >= 5)
Gene RIFs: 359   (req: > 3)
Antibodies: 705   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (547)
AMBRA1
Tbio
Novelty:  0.01626687
p_int:  0.990531659
p_ni:  0.009468341
Score:  0.379
Data Source:  BioPlex,STRINGDB
RGP1
Tbio
Novelty:  4
p_int:  0.8947732
p_ni:  1.8e-8
p_wrong:  0.105226782
Score:  0.485
Data Source:  BioPlex,STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.998
Data Source:  Reactome,STRINGDB
ELOB
Tbio
Novelty:  0.01315739
Score:  0.998
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.995
Data Source:  STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.994
Data Source:  Reactome,STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.992
Data Source:  Reactome,STRINGDB
LEPR
Tclin
Novelty:  0.00070587
Score:  0.99
Data Source:  Reactome,STRINGDB
LEP
Tbio
Novelty:  0.00005295
Score:  0.989
Data Source:  Reactome,STRINGDB
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
Score:  0.987
Data Source:  STRINGDB
Pathways (91)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
9
11
21
98.4
C-reactive protein measurement
2
8
8
96.8
apolipoprotein A 1 measurement
2
3
3
95.7
reticulocyte measurement
3
4
4
91.6
low density lipoprotein cholesterol measurement
4
2
4
88.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
21
98.4
C-reactive protein measurement
8
96.8
apolipoprotein A 1 measurement
3
95.7
reticulocyte measurement
4
91.6
low density lipoprotein cholesterol measurement
4
88.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
suppressor of cytokine signaling 3
715680
Mouse
MGI:1201791
12702
Rat
RGD:621087
89829
Dog
suppressor of cytokine signaling 3
VGNC:46650
442949
Horse
suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
suppressor of cytokine signaling 3
Mouse
Rat
Dog
suppressor of cytokine signaling 3
Horse
suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391]
Publication Statistics
PubMed Score 1051.56
PubMed score by year
PubTator Score 791.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title