SOAT1
Sterol O-acyltransferase 1
Protein Summary
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
- ENST00000367619
- ENSP00000356591
- ENSG00000057252
- ENST00000539888
- ENSP00000441356
- ENST00000540564
- ENSP00000445315
- ACACT
- ACACT1
- ACAT
- ACAT1
- SOAT
- STAT
- ACAT
- SOAT
- STAT
- ACACT
- ACAT1
- ACAT-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
kinase perturbation | 0.96 | ||
transcription factor binding site profile | 0.81 | ||
PubMedID | 0.8 | ||
molecular function | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 227.9 (req: < 5)
Gene RIFs: 78 (req: <= 3)
Antibodies: 165 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 227.9 (req: >= 5)
Gene RIFs: 78 (req: > 3)
Antibodies: 165 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 154
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0