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Tchem
SOAT1
Sterol O-acyltransferase 1

Protein Summary
Description
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367619
  • ENSP00000356591
  • ENSG00000057252
  • ENST00000539888
  • ENSP00000441356
  • ENST00000540564
  • ENSP00000445315

Symbol
  • ACACT
  • ACACT1
  • ACAT
  • ACAT1
  • SOAT
  • STAT
  • ACAT
  • SOAT
  • STAT
  • ACACT
  • ACAT1
  • ACAT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.96
transcription factor binding site profile
0.81
PubMedID
0.8
molecular function
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.9   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.9   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 154
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0