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Tbio
SNX7
Sorting nexin-7

Protein Summary
Description
May be involved in several stages of intracellular trafficking. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region like some family members, and its exact function is unknown. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jun 2010]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
virus perturbation
0.85
interacting protein
0.71
histone modification site profile
0.69
PubMedID
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.27   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.27   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
SNX4
Tbio
Novelty:  0.05441145
p_int:  0.999999988
p_ni:  1.2e-8
Score:  0.567
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.999267029
p_ni:  0.000732971
Score:  0.543
Data Source:  BioPlex,STRINGDB
BLOC1S2
Tbio
Novelty:  0.02346362
p_int:  0.98215165
p_ni:  0.013938481
p_wrong:  0.003909869
Score:  0.866
Data Source:  BioPlex,STRINGDB
SNX6
Tbio
Novelty:  0.05909848
Score:  0.779
Data Source:  STRINGDB
ASPM
Tbio
Novelty:  0.00599688
Score:  0.75
Data Source:  STRINGDB
SNX32
Tdark
Novelty:  0.66136036
Score:  0.722
Data Source:  STRINGDB
PLPPR5
Tdark
Family:  Enzyme
Novelty:  0.25352081
Score:  0.665
Data Source:  STRINGDB
FNDC7
Tdark
Novelty:  6.38662445
Score:  0.641
Data Source:  STRINGDB
VPS35
Tbio
Novelty:  0.00729892
Score:  0.628
Data Source:  STRINGDB
VPS29
Tbio
Novelty:  0.01335106
Score:  0.619
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
3
44
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
44
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 7
VGNC:1561
457048
Macaque
sorting nexin-7
716015
Mouse
MGI:1923811
76561
Rat
RGD:1305480
310815
Dog
sorting nexin 7
VGNC:46643
490148
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 7
Macaque
sorting nexin-7
Mouse
Rat
Dog
sorting nexin 7
Publication Statistics
PubMed Score 7.27
PubMed score by year
PubTator Score 2.79
PubTator score by year
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Related Publications
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PMID
Year
Title