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Tbio
SNX6
Sorting nexin-6

Protein Summary
Description
Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396526
  • ENSP00000379779
  • ENSG00000129515

Symbol
  • TFAF2
  • MSTP010
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
biological process
0.91
kinase perturbation
0.91
transcription factor perturbation
0.84
cellular component
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.35   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.35   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
SNX1
Tbio
Novelty:  0.01267973
p_int:  0.999999953
p_ni:  4.3e-8
p_wrong:  4e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
SNX32
Tdark
Novelty:  0.66136036
p_int:  0.99999968
p_ni:  2.69e-7
p_wrong:  5.1e-8
Score:  0.86
Data Source:  BioPlex,STRINGDB
KLHL1
Tbio
Novelty:  0.05206893
p_int:  0.999986714
p_ni:  0.000013286
Data Source:  BioPlex
POTEB
Tdark
Novelty:  0.48864918
p_int:  0.999199808
p_ni:  0.000800189
p_wrong:  3e-9
Data Source:  BioPlex
TSPYL1
Tbio
Novelty:  0.06381144
p_int:  0.998749519
p_ni:  0.001239197
p_wrong:  0.000011283
Data Source:  BioPlex
HENMT1
Tdark
Family:  Enzyme
Novelty:  0.17427834
p_int:  0.998657275
p_ni:  0.001342718
p_wrong:  7e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
TREML2
Tbio
Novelty:  0.05038302
p_int:  0.997102211
p_ni:  0.00289704
p_wrong:  7.49e-7
Score:  0.174
Data Source:  BioPlex,STRINGDB
USP46
Tbio
Family:  Enzyme
Novelty:  0.04594593
p_int:  0.996072705
p_ni:  0.003927236
p_wrong:  5.8e-8
Data Source:  BioPlex
TCTEX1D2
Tbio
Novelty:  0.15075459
p_int:  0.995285483
p_ni:  0.00471436
p_wrong:  1.57e-7
Data Source:  BioPlex
SPATA2
Tbio
Novelty:  0.10553772
p_int:  0.993877704
p_ni:  0.006122281
p_wrong:  1.6e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
82.5
serum alanine aminotransferase measurement
2
2
1
7.1
77.9
aspartate aminotransferase measurement
2
2
1
6.5
65
low density lipoprotein cholesterol measurement
2
2
2
43.8
self reported educational attainment
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
82.5
serum alanine aminotransferase measurement
1
7.1
77.9
aspartate aminotransferase measurement
1
6.5
65
low density lipoprotein cholesterol measurement
2
43.8
self reported educational attainment
1
12.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 6
VGNC:3312
467421
Macaque
sorting nexin-6-like
693755
Mouse
MGI:1919433
72183
Rat
RGD:1304647
362738
Dog
sorting nexin 6
VGNC:51689
490648
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 6
Macaque
sorting nexin-6-like
Mouse
Rat
Dog
sorting nexin 6
Publication Statistics
PubMed Score 26.35
PubMed score by year
PubTator Score 13.39
PubTator score by year
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Related Publications
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PMID
Year
Title