Tbio SNX4 Sorting nexin-4

Protein Summary

Description

Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• O95219
• B3KMH0
• B4DQV4
• D3DNA3

Gene Name

• SNX4

Ensembl ID

• ENST00000251775
• ENSP00000251775
• ENSG00000114520

Symbol

• ATG24B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
disease perturbation	0.93
interacting protein	0.88
histone modification site profile	0.8
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.22   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 228   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.22   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (168)

Explore Interacting Targets

1 – 10 of 168

• See Interactions on String-DB

SNX30

Tdark

Novelty:  78

p_int:  1

Score:  0.747

Data Source:  BioPlex,STRINGDB

SNX7

Tbio

Novelty:  0.1473151

p_int:  0.999999988

p_ni:  1.2e-8

Score:  0.567

Data Source:  BioPlex,STRINGDB

ANKMY2

Tdark

Novelty:  0.50777631

p_int:  0.999731179

p_ni:  0.000268821

Score:  0.233

Data Source:  BioPlex,STRINGDB

MECR

Tbio

Family:  Enzyme

Novelty:  0.01395965

p_int:  0.99948063

p_ni:  0.000519261

p_wrong:  1.08e-7

Data Source:  BioPlex

ABCB10

Tbio

Family:  Transporter

Novelty:  0.00351852

p_int:  0.984496356

p_ni:  0.015503644

Score:  0.261

Data Source:  BioPlex,STRINGDB

CACYBP

Tbio

Novelty:  0.02207811

p_int:  0.933642029

p_ni:  0.066357971

Score:  0.696

Data Source:  BioPlex,STRINGDB

DYNC1LI1

Tbio

Novelty:  0.02164556

Score:  0.928

Data Source:  STRINGDB

STX16

Tbio

Novelty:  0.02462523

Score:  0.927

Data Source:  STRINGDB

VAMP7

Tbio

Novelty:  0.00900603

Score:  0.924

Data Source:  STRINGDB

VAMP2

Tbio

Novelty:  0.00187736

Score:  0.921

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

KEGG (1)

PathwayCommons (1)

Find Similar Targets

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Endocytosis	309 targets	path:hsa04144

Name	Explore in Pharos	Explore in Source
Endocytosis	309 targets	path:hsa04144

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (5)

Components (7)

Processes (3)

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10

1 – 5 of 5

GO Term	Evidence	Assigned by
epidermal growth factor receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
insulin receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
leptin receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
transferrin receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
phosphatidylinositol binding	Inferred from Mutant Phenotype (IMP)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1	1	1		15.8
vitamin D measurement	EFO_0004631	2	1	2		7.9
urate measurement	EFO_0004531	1	1	1		5.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1		15.8
vitamin D measurement	EFO_0004631	2		7.9
urate measurement	EFO_0004531	1		5.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
Endosome
Lipid-binding
Membrane
Phosphoprotein
Protein transport
Reference proteome
Transport

GWAS Trait Find Similar Targets

No Header	No Header
body height
urate measurement
vitamin D measurement

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	sorting nexin 4	VGNC:2568	460652
Macaque	sorting nexin 4		716049
Mouse	sorting nexin 4	MGI:1916400	69150
Rat	sorting nexin 4	RGD:1309763	360725
Dog	sorting nexin 4	VGNC:46641	478595

Species	Name	OMA	EggNOG	Inparanoid
Chimp	sorting nexin 4
Macaque	sorting nexin 4
Mouse	sorting nexin 4
Rat	sorting nexin 4
Dog	sorting nexin 4

Publication Statistics

PubMed Score 20.22

PubMed score by year

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PubTator Score 10.22

PubTator score by year

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Related Publications

Text Mined References (18)

GeneRif Annotations (8)

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10

0 of 0

PMID	Year	Title