Protein Summary
Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012]
- ENST00000251775
- ENSP00000251775
- ENSG00000114520
- ATG24B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.99 | ||
disease perturbation | 0.93 | ||
interacting protein | 0.88 | ||
histone modification site profile | 0.8 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.22 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 228 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.22 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 228 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (168)
SNX7
Novelty: 0.1473151
p_int: 0.999999988
p_ni: 1.2e-8
Score: 0.567
Data Source: BioPlex,STRINGDB
ANKMY2
Novelty: 0.50777631
p_int: 0.999731179
p_ni: 0.000268821
Score: 0.233
Data Source: BioPlex,STRINGDB
MECR
Family: Enzyme
Novelty: 0.01395965
p_int: 0.99948063
p_ni: 0.000519261
p_wrong: 1.08e-7
Data Source: BioPlex
ABCB10
Family: Transporter
Novelty: 0.00351852
p_int: 0.984496356
p_ni: 0.015503644
Score: 0.261
Data Source: BioPlex,STRINGDB
CACYBP
Novelty: 0.02207811
p_int: 0.933642029
p_ni: 0.066357971
Score: 0.696
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
KEGG (1)
PathwayCommons (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Endocytosis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Endocytosis | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (5)
Components (7)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 15.8 | |||||
vitamin D measurement | 2 | 1 | 2 | 7.9 | |||||
urate measurement | 1 | 1 | 1 | 5.8 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body height | 1 | 15.8 | |||||
vitamin D measurement | 2 | 7.9 | |||||
urate measurement | 1 | 5.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | sorting nexin 4 | VGNC:2568 | 460652 | |||||
Macaque | sorting nexin 4 | 716049 | ||||||
Mouse | MGI:1916400 | 69150 | ||||||
Rat | RGD:1309763 | 360725 | ||||||
Dog | sorting nexin 4 | VGNC:46641 | 478595 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | sorting nexin 4 | |||||
Macaque | sorting nexin 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sorting nexin 4 | |||||
Publication Statistics
PubMed Score 20.22
PubMed score by year
PubTator Score 10.22
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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