You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SNX4
Sorting nexin-4

Protein Summary
Description
Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251775
  • ENSP00000251775
  • ENSG00000114520

Symbol
  • ATG24B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.93
interacting protein
0.88
histone modification site profile
0.8
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.22   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.22   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (168)
SNX30
Tdark
Novelty:  78
p_int:  1
Score:  0.747
Data Source:  BioPlex,STRINGDB
SNX7
Tbio
Novelty:  0.1473151
p_int:  0.999999988
p_ni:  1.2e-8
Score:  0.567
Data Source:  BioPlex,STRINGDB
ANKMY2
Tdark
Novelty:  0.50777631
p_int:  0.999731179
p_ni:  0.000268821
Score:  0.233
Data Source:  BioPlex,STRINGDB
MECR
Tbio
Family:  Enzyme
Novelty:  0.01395965
p_int:  0.99948063
p_ni:  0.000519261
p_wrong:  1.08e-7
Data Source:  BioPlex
ABCB10
Tbio
Family:  Transporter
Novelty:  0.00351852
p_int:  0.984496356
p_ni:  0.015503644
Score:  0.261
Data Source:  BioPlex,STRINGDB
CACYBP
Tbio
Novelty:  0.02207811
p_int:  0.933642029
p_ni:  0.066357971
Score:  0.696
Data Source:  BioPlex,STRINGDB
DYNC1LI1
Tbio
Novelty:  0.02164556
Score:  0.928
Data Source:  STRINGDB
STX16
Tbio
Novelty:  0.02462523
Score:  0.927
Data Source:  STRINGDB
VAMP7
Tbio
Novelty:  0.00900603
Score:  0.924
Data Source:  STRINGDB
VAMP2
Tbio
Novelty:  0.00187736
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
15.8
vitamin D measurement
2
1
2
7.9
urate measurement
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
15.8
vitamin D measurement
2
7.9
urate measurement
1
5.8
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 4
VGNC:2568
460652
Macaque
sorting nexin 4
716049
Mouse
MGI:1916400
69150
Rat
RGD:1309763
360725
Dog
sorting nexin 4
VGNC:46641
478595
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 4
Macaque
sorting nexin 4
Mouse
Rat
Dog
sorting nexin 4
Publication Statistics
PubMed Score 20.22
PubMed score by year
PubTator Score 10.22
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title