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Tbio
SNX33
Sorting nexin-33

Protein Summary
Description
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308527
  • ENSP00000311427
  • ENSG00000173548

Symbol
  • SH3PX3
  • SH3PXD3C
  • SNX30
  • SNX30
  • SH3PX3
  • SH3PXD3C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
protein domain
0.73
cellular component
0.69
biological process
0.66
transcription factor binding site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.03   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.03   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
HNRNPK
Tbio
Novelty:  0.00354731
p_int:  0.999998655
p_ni:  0.000001345
Score:  0.188
Data Source:  BioPlex,STRINGDB
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.999987918
p_ni:  0.000012082
Data Source:  BioPlex
FASLG
Tbio
Novelty:  0.0003303
p_int:  0.999986017
p_ni:  0.00001391
p_wrong:  7.3e-8
Score:  0.513
Data Source:  BioPlex,STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.999980358
p_ni:  0.000019642
Data Source:  BioPlex
CD44
Tbio
Novelty:  0.00011321
p_int:  0.999952844
p_ni:  0.000047156
Score:  0.153
Data Source:  BioPlex,STRINGDB
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.999952833
p_ni:  0.000046983
p_wrong:  1.84e-7
Score:  0.162
Data Source:  BioPlex,STRINGDB
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
p_int:  0.999176494
p_ni:  0.00073287
p_wrong:  0.000090636
Data Source:  BioPlex
NCKIPSD
Tbio
Novelty:  0.07453111
p_int:  0.996481986
p_ni:  0.000722628
p_wrong:  0.002795386
Score:  0.206
Data Source:  BioPlex,STRINGDB
NAA10
Tbio
Family:  Enzyme
Novelty:  0.00086809
p_int:  0.995346628
p_ni:  0.004425658
p_wrong:  0.000227714
Data Source:  BioPlex
ENC1
Tbio
Novelty:  0.01942998
Score:  0.799
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
4
4
73.1
glomerular filtration rate
1
4
4
70.9
serum urea measurement
1
2
2
49.5
body height
1
1
1
42.3
1
1
0
1.1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
4
73.1
glomerular filtration rate
4
70.9
serum urea measurement
2
49.5
body height
1
42.3
0
1.1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 33
VGNC:13423
453761
Macaque
sorting nexin 33
706309
Mouse
MGI:2443239
235406
Rat
RGD:1307898
315696
Dog
sorting nexin 33
VGNC:46640
487657
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 33
Macaque
sorting nexin 33
Mouse
Rat
Dog
sorting nexin 33
Publication Statistics
PubMed Score 8.03
PubMed score by year
PubTator Score 3.67
PubTator score by year
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Related Publications
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PMID
Year
Title