Tbio SNX33 Sorting nexin-33

Protein Summary

Description

Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q8WV41
• B1NM17

Gene Name

• SNX33

Ensembl ID

• ENST00000308527
• ENSP00000311427
• ENSG00000173548

Symbol

• SH3PX3
• SH3PXD3C
• SNX30
• SNX30
• SH3PX3
• SH3PXD3C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.92
protein domain	0.73
cellular component	0.69
biological process	0.66
transcription factor binding site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.03   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.03   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (69)

Explore Interacting Targets

1 – 10 of 69

• See Interactions on String-DB

HNRNPK

Tbio

Novelty:  0.00354731

p_int:  0.999998655

p_ni:  0.000001345

Score:  0.188

Data Source:  BioPlex,STRINGDB

KBTBD7

Tdark

Novelty:  0.4947466

p_int:  0.999987918

p_ni:  0.000012082

Data Source:  BioPlex

FASLG

Tbio

Novelty:  0.0003303

p_int:  0.999986017

p_ni:  0.00001391

p_wrong:  7.3e-8

Score:  0.513

Data Source:  BioPlex,STRINGDB

SSSCA1

Tdark

Novelty:  0.53523038

p_int:  0.999980358

p_ni:  0.000019642

Data Source:  BioPlex

CD44

Tbio

Novelty:  0.00011321

p_int:  0.999952844

p_ni:  0.000047156

Score:  0.153

Data Source:  BioPlex,STRINGDB

SDC2

Tbio

Novelty:  0.00597758

p_int:  0.999952833

p_ni:  0.000046983

p_wrong:  1.84e-7

Score:  0.162

Data Source:  BioPlex,STRINGDB

GPR156

Tdark

Family:  GPCR

Novelty:  0.39183023

p_int:  0.999176494

p_ni:  0.00073287

p_wrong:  0.000090636

Data Source:  BioPlex

NCKIPSD

Tbio

Novelty:  0.07453111

p_int:  0.996481986

p_ni:  0.000722628

p_wrong:  0.002795386

Score:  0.206

Data Source:  BioPlex,STRINGDB

NAA10

Tbio

Family:  Enzyme

Novelty:  0.00086809

p_int:  0.995346628

p_ni:  0.004425658

p_wrong:  0.000227714

Data Source:  BioPlex

ENC1

Tbio

Novelty:  0.01942998

Score:  0.799

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

PathwayCommons (1)

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Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: netpath	EGFR1	472 targets	PathwayCommons: netpath

Name	Explore in Pharos	Explore in Source
EGFR1	472 targets	PathwayCommons: netpath

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (20)

Functions (2)

Components (5)

Processes (13)

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1 – 2 of 2

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
phosphatidylinositol binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (10)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
creatinine measurement	EFO_0004518	1	4	4		73.1
glomerular filtration rate	EFO_0005208	1	4	4		70.9
serum urea measurement	EFO_0009795	1	2	2		49.5
body height	EFO_0004339	1	1	1		42.3
type II diabetes mellitus	EFO_0001360	1	1	0	1.1	38.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
creatinine measurement	EFO_0004518	4		73.1
glomerular filtration rate	EFO_0005208	4		70.9
serum urea measurement	EFO_0009795	2		49.5
body height	EFO_0004339	1		42.3
type II diabetes mellitus	EFO_0001360	0	1.1	38.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Endocytosis
Membrane
Mitosis
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
body height
creatinine measurement
glomerular filtration rate
hip circumference
intraocular pressure measurement
serum urea measurement
sex hormone-binding globulin measurement
type II diabetes mellitus
urate measurement

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	sorting nexin 33	VGNC:13423	453761
Macaque	sorting nexin 33		706309
Mouse	sorting nexin 33	MGI:2443239	235406
Rat	sorting nexin 33	RGD:1307898	315696
Dog	sorting nexin 33	VGNC:46640	487657

Species	Name	OMA	EggNOG	Inparanoid
Chimp	sorting nexin 33
Macaque	sorting nexin 33
Mouse	sorting nexin 33
Rat	sorting nexin 33
Dog	sorting nexin 33

Publication Statistics

PubMed Score 8.03

PubMed score by year

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PubTator Score 3.67

PubTator score by year

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Related Publications

Text Mined References (15)

GeneRif Annotations (6)

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10

0 of 0

PMID	Year	Title