Protein Summary
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
- ENST00000308527
- ENSP00000311427
- ENSG00000173548
- SH3PX3
- SH3PXD3C
- SNX30
- SNX30
- SH3PX3
- SH3PXD3C
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.92 | ||
protein domain | 0.73 | ||
cellular component | 0.69 | ||
biological process | 0.66 | ||
transcription factor binding site profile | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.03 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 120 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.03 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 120 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (69)
HNRNPK
Novelty: 0.00354731
p_int: 0.999998655
p_ni: 0.000001345
Score: 0.188
Data Source: BioPlex,STRINGDB
FASLG
Novelty: 0.0003303
p_int: 0.999986017
p_ni: 0.00001391
p_wrong: 7.3e-8
Score: 0.513
Data Source: BioPlex,STRINGDB
CD44
Novelty: 0.00011321
p_int: 0.999952844
p_ni: 0.000047156
Score: 0.153
Data Source: BioPlex,STRINGDB
SDC2
Novelty: 0.00597758
p_int: 0.999952833
p_ni: 0.000046983
p_wrong: 1.84e-7
Score: 0.162
Data Source: BioPlex,STRINGDB
GPR156
Family: GPCR
Novelty: 0.39183023
p_int: 0.999176494
p_ni: 0.00073287
p_wrong: 0.000090636
Data Source: BioPlex
NCKIPSD
Novelty: 0.07453111
p_int: 0.996481986
p_ni: 0.000722628
p_wrong: 0.002795386
Score: 0.206
Data Source: BioPlex,STRINGDB
NAA10
Family: Enzyme
Novelty: 0.00086809
p_int: 0.995346628
p_ni: 0.004425658
p_wrong: 0.000227714
Data Source: BioPlex
Nearest Tclin Targets
Pathways (1)
PathwayCommons (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
PathwayCommons: netpath | EGFR1 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
EGFR1 | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (2)
Components (5)
Processes (13)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
creatinine measurement | 1 | 4 | 4 | 73.1 | |||||
glomerular filtration rate | 1 | 4 | 4 | 70.9 | |||||
serum urea measurement | 1 | 2 | 2 | 49.5 | |||||
body height | 1 | 1 | 1 | 42.3 | |||||
1 | 1 | 0 | 1.1 | 38.2 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
creatinine measurement | 4 | 73.1 | |||||
glomerular filtration rate | 4 | 70.9 | |||||
serum urea measurement | 2 | 49.5 | |||||
body height | 1 | 42.3 | |||||
0 | 1.1 | 38.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | sorting nexin 33 | VGNC:13423 | 453761 | |||||
Macaque | sorting nexin 33 | 706309 | ||||||
Mouse | MGI:2443239 | 235406 | ||||||
Rat | RGD:1307898 | 315696 | ||||||
Dog | sorting nexin 33 | VGNC:46640 | 487657 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | sorting nexin 33 | |||||
Macaque | sorting nexin 33 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sorting nexin 33 | |||||
Publication Statistics
PubMed Score 8.03
PubMed score by year
PubTator Score 3.67
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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