You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SNX3
Sorting nexin-3

Protein Summary
Description
Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230085
  • ENSP00000230085
  • ENSG00000112335
  • ENST00000349379
  • ENSP00000296991
  • ENST00000368979
  • ENSP00000357975
  • ENST00000426155
  • ENSP00000401779

Symbol
  • SDP3
  • Grd19
  • MCOPS8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.99
biological process
0.88
hub protein
0.85
transcription factor binding site profile
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.24   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.24   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.999763651
p_ni:  0.000236343
p_wrong:  6e-9
Score:  0.167
Data Source:  BioPlex,STRINGDB
SNX12
Tbio
Novelty:  0.16113428
p_int:  0.999571203
p_ni:  0.000428796
Score:  0.807
Data Source:  BioPlex,STRINGDB
VPS26A
Tbio
Novelty:  0.01804654
p_int:  0.999454945
p_ni:  0.000544696
p_wrong:  3.6e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.999422381
p_ni:  0.000577548
p_wrong:  7.1e-8
Data Source:  BioPlex
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
p_int:  0.999330553
p_ni:  0.000669433
p_wrong:  1.5e-8
Score:  0.159
Data Source:  BioPlex,STRINGDB
VPS26B
Tdark
Novelty:  0.25702869
p_int:  0.998695067
p_ni:  0.001304933
Score:  0.944
Data Source:  BioPlex,STRINGDB
PTER
Tbio
Family:  Enzyme
Novelty:  0.01347498
p_int:  0.99624948
p_ni:  0.002316472
p_wrong:  0.001434048
Data Source:  BioPlex
VPS35
Tbio
Novelty:  0.00729892
p_int:  0.996229081
p_ni:  0.003770918
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.995651881
p_ni:  0.004348115
p_wrong:  4e-9
Data Source:  BioPlex
CAV3
Tbio
Novelty:  0.00190092
p_int:  0.995611779
p_ni:  0.004388219
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Signal Transduction
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Signal Transduction
Signaling by WNT
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
36.9
alcohol consumption measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
36.9
alcohol consumption measurement
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 3
VGNC:3706
107975233
Macaque
sorting nexin 3
700989
Mouse
MGI:1860188
54198
Dog
sorting nexin 3
VGNC:46636
613007
Horse
sorting nexin 3
VGNC:23425
100066515
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 3
Macaque
sorting nexin 3
Mouse
Dog
sorting nexin 3
Horse
sorting nexin 3
Publication Statistics
PubMed Score 46.24
PubMed score by year
PubTator Score 20.32
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title