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Tbio
SNX27
Sorting nexin-27

Protein Summary
Description
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368843
  • ENSP00000357836
  • ENSG00000143376
  • ENST00000458013
  • ENSP00000400333

Symbol
  • KIAA0488
  • MRT1
  • MY014
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
interacting protein
0.74
protein domain
0.73
kinase perturbation
0.71
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.89   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.89   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (150)
APOA1
Tbio
Novelty:  0.0001216
p_int:  0.999999107
p_ni:  8.92e-7
p_wrong:  2e-9
Data Source:  BioPlex
CDS1
Tbio
Family:  Enzyme
Novelty:  0.08094799
p_int:  0.999997523
p_ni:  0.000002477
Data Source:  BioPlex
CP
Tbio
Novelty:  0.00103285
p_int:  0.999995688
p_ni:  0.000004301
p_wrong:  1.1e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
HP
Tbio
Novelty:  0.00016649
p_int:  0.999995523
p_ni:  0.000004427
p_wrong:  4.9e-8
Data Source:  BioPlex
C3
Tclin
Novelty:  0.00019115
p_int:  0.999994097
p_ni:  0.000005903
Data Source:  BioPlex
IGHA2
Tbio
p_int:  0.999984382
p_ni:  0.000015618
Data Source:  BioPlex
BPIFA1
Tbio
Novelty:  0.00586117
p_int:  0.999982239
p_ni:  0.000011377
p_wrong:  0.000006384
Data Source:  BioPlex
C4A
Tbio
Novelty:  0.00062793
p_int:  0.999978144
p_ni:  0.000021856
Data Source:  BioPlex
IGHG3
Tclin
p_int:  0.999969273
p_ni:  0.000008724
p_wrong:  0.000022003
Data Source:  BioPlex
LTF
Tbio
Novelty:  0.00114254
p_int:  0.999965689
p_ni:  0.000034311
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
4
1.1
83.2
leukocyte count
1
1
1
76.5
neutrophil count
1
1
1
73.1
vitamin D measurement
1
2
2
67.6
educational attainment
1
2
2
60.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
83.2
leukocyte count
1
76.5
neutrophil count
1
73.1
vitamin D measurement
2
67.6
educational attainment
2
60.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin family member 27
VGNC:10986
457299
Macaque
sorting nexin family member 27
710990
Mouse
MGI:1923992
76742
Rat
RGD:628705
260323
Dog
sorting nexin family member 27
VGNC:46634
483200
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin family member 27
Macaque
sorting nexin family member 27
Mouse
Rat
Dog
sorting nexin family member 27
Publication Statistics
PubMed Score 66.89
PubMed score by year
PubTator Score 43.56
PubTator score by year
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Related Publications
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PMID
Year
Title