Tbio SNX25 Sorting nexin-25

Protein Summary

Description

May be involved in several stages of intracellular trafficking.

Uniprot Accession IDs

• Q9H3E2
• Q3ZT30
• Q8N6K3

Gene Name

• SNX25

Ensembl ID

• ENST00000264694
• ENSP00000264694
• ENSG00000109762
• ENST00000504273
• ENSP00000426255
• ENST00000618785
• ENSP00000483653

Symbol

• SBBI31
• MSTP043

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.93
kinase perturbation	0.88
transcription factor perturbation	0.68
tissue sample	0.66
virus perturbation	0.59

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Sorting Nexin-25

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Sorting Nexin-25

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.17   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.17   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (46)

Explore Interacting Targets

1 – 10 of 46

• See Interactions on String-DB

VAPB

Tbio

Novelty:  0.00542377

p_int:  0.999999956

p_ni:  4.4e-8

p_wrong:  1e-9

Data Source:  BioPlex

ATP6V0D1

Tbio

Family:  Enzyme

Novelty:  0.05146108

p_int:  0.999949907

p_ni:  0.000048718

p_wrong:  0.000001375

Score:  0.197

Data Source:  BioPlex,STRINGDB

TSPAN5

Tbio

Novelty:  0.08879443

p_int:  0.999940052

p_ni:  0.000059939

p_wrong:  9e-9

Score:  0.179

Data Source:  BioPlex,STRINGDB

COA3

Tbio

Family:  Enzyme

Novelty:  0.04949473

p_int:  0.99978256

p_ni:  0.000212017

p_wrong:  0.000005423

Data Source:  BioPlex

B4GAT1

Tbio

Family:  Enzyme

Novelty:  0.14959923

p_int:  0.999360865

p_ni:  0.000636282

p_wrong:  0.000002853

Score:  0.199

Data Source:  BioPlex,STRINGDB

HSPB8

Tbio

Novelty:  0.00298618

Score:  0.752

Data Source:  STRINGDB

SNX21

Tdark

Novelty:  0.32916633

Score:  0.682

Data Source:  STRINGDB

SAMD12

Tbio

Novelty:  0.07144305

Score:  0.679

Data Source:  STRINGDB

SNX27

Tbio

Novelty:  0.02419724

Score:  0.677

Data Source:  STRINGDB

KIF1B

Tbio

Novelty:  0.00984332

Score:  0.657

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (2)

Components (2)

Processes (4)

Find Similar Targets

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1 – 2 of 2

GO Term	Evidence	Assigned by
phosphatidylinositol binding	Inferred from Electronic Annotation (IEA)	InterPro
type I transforming growth factor beta receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
systemic scleroderma	EFO_0000717	1	1	0	1.5	15.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
systemic scleroderma	EFO_0000717	0	1.5	15.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Coiled coil
Complete proteome
Endosome
Membrane
Phosphoprotein
Polymorphism
Protein transport
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
systemic scleroderma

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
homeostasis/metabolism phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	sorting nexin 25	VGNC:696	461634
Macaque	sorting nexin 25		699548
Mouse	sorting nexin 25	MGI:2142610	102141
Rat	sorting nexin 25	RGD:1310150	306471
Dog	sorting nexin 25	VGNC:46633	475629

Species	Name	OMA	EggNOG	Inparanoid
Chimp	sorting nexin 25
Macaque	sorting nexin 25
Mouse	sorting nexin 25
Rat	sorting nexin 25
Dog	sorting nexin 25

Publication Statistics

PubMed Score 8.17

PubMed score by year

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PubTator Score 2.81

PubTator score by year

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Related Publications

Text Mined References (7)

GeneRif Annotations (3)

Items per page:

10

0 of 0

PMID	Year	Title