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Tbio
SNX25
Sorting nexin-25

Protein Summary
Description
May be involved in several stages of intracellular trafficking.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264694
  • ENSP00000264694
  • ENSG00000109762
  • ENST00000504273
  • ENSP00000426255
  • ENST00000618785
  • ENSP00000483653

Symbol
  • SBBI31
  • MSTP043
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
kinase perturbation
0.88
transcription factor perturbation
0.68
tissue sample
0.66
virus perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.17   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.17   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999999956
p_ni:  4.4e-8
p_wrong:  1e-9
Data Source:  BioPlex
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
p_int:  0.999949907
p_ni:  0.000048718
p_wrong:  0.000001375
Score:  0.197
Data Source:  BioPlex,STRINGDB
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.999940052
p_ni:  0.000059939
p_wrong:  9e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
COA3
Tbio
Family:  Enzyme
Novelty:  0.04949473
p_int:  0.99978256
p_ni:  0.000212017
p_wrong:  0.000005423
Data Source:  BioPlex
B4GAT1
Tbio
Family:  Enzyme
Novelty:  0.14959923
p_int:  0.999360865
p_ni:  0.000636282
p_wrong:  0.000002853
Score:  0.199
Data Source:  BioPlex,STRINGDB
HSPB8
Tbio
Novelty:  0.00298618
Score:  0.752
Data Source:  STRINGDB
SNX21
Tdark
Novelty:  0.32916633
Score:  0.682
Data Source:  STRINGDB
SAMD12
Tbio
Novelty:  0.07144305
Score:  0.679
Data Source:  STRINGDB
SNX27
Tbio
Novelty:  0.02419724
Score:  0.677
Data Source:  STRINGDB
KIF1B
Tbio
Novelty:  0.00984332
Score:  0.657
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.5
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 25
VGNC:696
461634
Macaque
sorting nexin 25
699548
Mouse
MGI:2142610
102141
Rat
RGD:1310150
306471
Dog
sorting nexin 25
VGNC:46633
475629
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 25
Macaque
sorting nexin 25
Mouse
Rat
Dog
sorting nexin 25
Publication Statistics
PubMed Score 8.17
PubMed score by year
PubTator Score 2.81
PubTator score by year
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Related Publications
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PMID
Year
Title