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Tdark
SNX24
Sorting nexin-24

Protein Summary
Description
May be involved in several stages of intracellular trafficking.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261369
  • ENSP00000261369
  • ENSG00000064652
  • ENST00000506996
  • ENSP00000422535
  • ENST00000513881
  • ENSP00000424149

Symbol
  • SBBI31
  • PRO1284
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor perturbation
0.84
kinase perturbation
0.76
disease perturbation
0.68
transcription factor binding site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.73   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.73   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
CSNK1E
Tclin
Family:  Kinase
Novelty:  0.00891859
p_int:  0.999999983
p_ni:  1.7e-8
Score:  0.226
Data Source:  BioPlex,STRINGDB
CSNK1A1
Tchem
Family:  Kinase
Novelty:  0.00636472
p_int:  0.999999981
p_ni:  1.9e-8
Score:  0.512
Data Source:  BioPlex,STRINGDB
GAPVD1
Tbio
Family:  Enzyme
Novelty:  0.13142098
p_int:  0.99999995
p_ni:  5e-8
Score:  0.866
Data Source:  BioPlex,STRINGDB
LONRF2
Tdark
Family:  Enzyme
Novelty:  1.01811251
p_int:  0.999999417
p_ni:  5.8e-8
p_wrong:  5.25e-7
Score:  0.175
Data Source:  BioPlex,STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.999999179
p_ni:  8.21e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
SPATA46
Tdark
Novelty:  0.327066
p_int:  0.999998583
p_ni:  0.000001416
p_wrong:  1e-9
Score:  0.686
Data Source:  BioPlex,STRINGDB
SNX22
Tdark
Novelty:  0.26806147
p_int:  0.999997986
p_ni:  7e-9
p_wrong:  0.000002007
Score:  0.833
Data Source:  BioPlex,STRINGDB
UGP2
Tbio
Family:  Enzyme
Novelty:  0.00760963
p_int:  0.999997805
p_ni:  0.000002195
Score:  0.247
Data Source:  BioPlex,STRINGDB
CSNK1D
Tchem
Family:  Kinase
Novelty:  0.00896935
p_int:  0.999991545
p_ni:  0.000008455
Score:  0.335
Data Source:  BioPlex,STRINGDB
PACS1
Tbio
Novelty:  0.02030091
p_int:  0.999921071
p_ni:  0.000062163
p_wrong:  0.000016766
Score:  0.266
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
93.5
platelet crit
2
2
2
90.4
myeloid white cell count
1
1
1
56.6
1
1
1
46.9
heart rate response to recovery post exercise
2
1
2
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
93.5
platelet crit
2
90.4
myeloid white cell count
1
56.6
1
46.9
heart rate response to recovery post exercise
2
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sorting nexin 24
700621
Mouse
MGI:1916476
69226
Rat
RGD:1306864
361328
Dog
sorting nexin 24
VGNC:51763
608666
Horse
sorting nexin 24
VGNC:23422
100630743
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sorting nexin 24
Mouse
Rat
Dog
sorting nexin 24
Horse
sorting nexin 24
Publication Statistics
PubMed Score 4.73
PubMed score by year
PubTator Score 0.52
PubTator score by year
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Related Publications
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PMID
Year
Title