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Tdark
SNX21
Sorting nexin-21

Protein Summary
Description
Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. The specific function of this protein has not been determined. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342644
  • ENSP00000344586
  • ENSG00000124104
  • ENST00000462307
  • ENSP00000420169
  • ENST00000491381
  • ENSP00000418593

Symbol
  • C20orf161
  • SNXL
  • SNX-L
  • PP3993
  • C20orf161
  • dJ337O18.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.72
tissue sample
0.65
histone modification site profile
0.62
virus perturbation
0.59
cell type or tissue
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.34   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.34   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
MARCKSL1
Tbio
Novelty:  0.01290798
p_int:  0.999992422
p_ni:  0.000007578
Score:  0.153
Data Source:  BioPlex,STRINGDB
HTT
Tchem
Novelty:  0.00034051
p_int:  0.999987201
p_ni:  0.000012799
Data Source:  BioPlex
FAAP100
Tdark
Novelty:  0.1698504
p_int:  0.999524116
p_ni:  0.000475882
p_wrong:  3e-9
Data Source:  BioPlex
EIF2A
Tbio
Novelty:  0.08652858
p_int:  0.997102592
p_ni:  0.00158348
p_wrong:  0.001313927
Data Source:  BioPlex
TRIM65
Tbio
Novelty:  0.09830696
p_int:  0.995798984
p_ni:  0.004200798
p_wrong:  2.18e-7
Score:  0.159
Data Source:  BioPlex,STRINGDB
PMS1
Tbio
Family:  TF
Novelty:  0.00444827
p_int:  0.995248217
p_ni:  0.001610794
p_wrong:  0.00314099
Score:  0.158
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.993656256
p_ni:  0.006343744
Data Source:  BioPlex
EME1
Tbio
Family:  Enzyme
Novelty:  0.017415
p_int:  0.990303192
p_ni:  0.008496783
p_wrong:  0.001200025
Data Source:  BioPlex
VPS13B
Tbio
Novelty:  0.02154769
p_int:  0.988048871
p_ni:  0.011902133
p_wrong:  0.000048996
Score:  0.159
Data Source:  BioPlex,STRINGDB
SLC4A7
Tbio
Family:  Transporter
Novelty:  0.011156
p_int:  0.979931423
p_ni:  0.016818235
p_wrong:  0.003250342
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (45)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
26
11
33
3.3
99.3
high density lipoprotein cholesterol measurement
89
17
98
99.2
lipid measurement
18
6
18
98.9
free cholesterol measurement
15
7
15
96.4
very low density lipoprotein cholesterol measurement
45
9
45
96.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
33
3.3
99.3
high density lipoprotein cholesterol measurement
98
99.2
lipid measurement
18
98.9
free cholesterol measurement
15
96.4
very low density lipoprotein cholesterol measurement
45
96.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin family member 21
VGNC:6267
469956
Mouse
MGI:1917729
101113
Rat
RGD:2323753
100362940
Dog
sorting nexin family member 21
VGNC:46631
485900
Horse
sorting nexin family member 21
VGNC:23420
100071099
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin family member 21
Mouse
Rat
Dog
sorting nexin family member 21
Horse
sorting nexin family member 21
Publication Statistics
PubMed Score 3.34
PubMed score by year
PubTator Score 2.03
PubTator score by year
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Related Publications
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PMID
Year
Title