Protein Summary
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity o ...more
- ENST00000379516
- ENSP00000368831
- ENSG00000205302
- ENST00000514949
- ENSP00000421663
- TRG-9
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.99 | ||
disease perturbation | 0.9 | ||
protein complex | 0.68 | ||
histone modification site profile | 0.67 | ||
tissue sample | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.13 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 164 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.13 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 164 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (166)
SNX1
Novelty: 0.01267973
p_int: 0.999997789
p_ni: 0.000002211
Score: 0.976
Data Source: BioPlex,STRINGDB
C1orf87
Novelty: 0.03162594
p_int: 0.999992567
p_ni: 0.000007433
Score: 0.239
Data Source: BioPlex,STRINGDB
HENMT1
Family: Enzyme
Novelty: 0.17427834
p_int: 0.997867296
p_ni: 0.002132704
Score: 0.167
Data Source: BioPlex,STRINGDB
VAPB
Novelty: 0.00542377
p_int: 0.997852536
p_ni: 0.002147464
Score: 0.315
Data Source: BioPlex,STRINGDB
C11orf42
Novelty: 3.71428571
p_int: 0.991861947
p_ni: 0.008138053
Score: 0.214
Data Source: BioPlex,STRINGDB
TCTEX1D2
Novelty: 0.15075459
p_int: 0.989933735
p_ni: 0.010066265
Score: 0.181
Data Source: BioPlex,STRINGDB
DNM3
Novelty: 0.02365643
p_int: 0.989805942
p_ni: 0.010194057
p_wrong: 1e-9
Score: 0.301
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (4)
KEGG (1)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Golgi Associated Vesicle Biogenesis | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Reactome | trans-Golgi Network Vesicle Budding | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Golgi Associated Vesicle Biogenesis | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
trans-Golgi Network Vesicle Budding | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (8)
Components (11)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 2 | 2 | 2 | 90.9 | |||||
platelet crit | 2 | 2 | 2 | 90.4 | |||||
myeloid white cell count | 1 | 1 | 1 | 56.6 | |||||
neutrophil count | 2 | 1 | 2 | 10.2 | |||||
leukocyte count | 1 | 1 | 1 | 9.9 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean platelet volume | 2 | 90.9 | |||||
platelet crit | 2 | 90.4 | |||||
myeloid white cell count | 1 | 56.6 | |||||
neutrophil count | 2 | 10.2 | |||||
leukocyte count | 1 | 9.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | sorting nexin 2 | VGNC:4170 | 462022 | |||||
Macaque | sorting nexin 2 | 700507 | ||||||
Mouse | MGI:1915054 | 67804 | ||||||
Rat | RGD:1310291 | 291464 | ||||||
Dog | sorting nexin 2 | VGNC:46629 | 474657 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | sorting nexin 2 | |||||
Macaque | sorting nexin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sorting nexin 2 | |||||
Publication Statistics
PubMed Score 24.13
PubMed score by year
PubTator Score 25.50
PubTator score by year
Related Publications
Text Mined References (36)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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