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Tbio
SNX18
Sorting nexin-18

Protein Summary
Description
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [prov ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326277
  • ENSP00000317332
  • ENSG00000178996
  • ENST00000343017
  • ENSP00000342276
  • ENST00000381410
  • ENSP00000370817

Symbol
  • SH3PXD3B
  • SNAG1
  • SNAG1
  • SH3PX2
  • SH3PXD3B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
kinase perturbation
0.88
cellular component
0.84
microRNA
0.75
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.8   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.8   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (167)
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.99999928
p_ni:  7.2e-7
Data Source:  BioPlex
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999997369
p_ni:  0.000002631
Data Source:  BioPlex
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999950186
p_ni:  0.000049811
p_wrong:  3e-9
Score:  0.668
Data Source:  BioPlex,STRINGDB
RELL1
Tbio
Novelty:  0.28949625
p_int:  0.999808407
p_ni:  0.000191593
Score:  0.189
Data Source:  BioPlex,STRINGDB
CD44
Tbio
Novelty:  0.00011321
p_int:  0.999701462
p_ni:  0.000298468
p_wrong:  7e-8
Data Source:  BioPlex
GRAP2
Tbio
Novelty:  0.00503901
p_int:  0.999250195
p_ni:  0.000749745
p_wrong:  6e-8
Score:  0.351
Data Source:  BioPlex,STRINGDB
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.998788981
p_ni:  0.001210921
p_wrong:  9.8e-8
Data Source:  BioPlex
ZNF74
Tbio
Family:  TF
Novelty:  0.10554307
p_int:  0.995709324
p_ni:  0.004263827
p_wrong:  0.000026849
Data Source:  BioPlex
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.994677725
p_ni:  0.00511279
p_wrong:  0.000209485
Data Source:  BioPlex
ZNF764
Tdark
Family:  TF
Novelty:  0.76308829
p_int:  0.985872097
p_ni:  0.010221266
p_wrong:  0.003906638
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
2
2
36.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
2
36.2
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 18
VGNC:4169
471817
Macaque
sorting nexin 18
704669
Mouse
MGI:2137642
170625
Rat
RGD:1310367
310097
Dog
sorting nexin 18
VGNC:46627
610530
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 18
Macaque
sorting nexin 18
Mouse
Rat
Dog
sorting nexin 18
Publication Statistics
PubMed Score 10.80
PubMed score by year
PubTator Score 8.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title