Tbio SNX17 Sorting nexin-17

Protein Summary

Description

Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q15036
• B4DQM7
• Q53HN7
• Q6IAS3

Gene Name

• SNX17

Ensembl ID

• ENST00000233575
• ENSP00000233575
• ENSG00000115234
• ENST00000537606
• ENSP00000439208

Symbol

• KIAA0064

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
transcription factor binding site profile	0.9
histone modification site profile	0.88
kinase perturbation	0.88
cell type or tissue	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.55   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.55   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (98)

Explore Interacting Targets

1 – 10 of 98

• See Interactions on String-DB

RHEX

Tbio

Novelty:  0.20957256

p_int:  0.999999952

p_ni:  4.8e-8

Score:  0.186

Data Source:  BioPlex,STRINGDB

VIPR2

Tchem

Family:  GPCR

Novelty:  0.00463802

p_int:  0.999998845

p_ni:  0.000001155

Data Source:  BioPlex

COPZ2

Tdark

Novelty:  0.21561497

p_int:  0.995390637

p_ni:  0.004609363

Data Source:  BioPlex

PITRM1

Tchem

Family:  Enzyme

Novelty:  0.08067518

p_int:  0.989544059

p_ni:  0.010455941

Data Source:  BioPlex

NPDC1

Tbio

Novelty:  0.05766647

p_int:  0.986022022

p_ni:  0.013977978

Score:  0.201

Data Source:  BioPlex,STRINGDB

MANSC1

Tdark

Novelty:  0.91681036

p_int:  0.981779798

p_ni:  0.018219135

p_wrong:  0.000001068

Data Source:  BioPlex

GMPR2

Tbio

Family:  Enzyme

Novelty:  0.16707153

p_int:  0.97768339

p_ni:  0.022316582

p_wrong:  2.7e-8

Score:  0.529

Data Source:  BioPlex,STRINGDB

MTM1

Tbio

Family:  Enzyme

Novelty:  0.00413329

p_int:  0.977387115

p_ni:  0.022612885

Score:  0.234

Data Source:  BioPlex,STRINGDB

IL20RA

Tbio

Novelty:  0.02416816

p_int:  0.968132301

p_ni:  0.031867699

Data Source:  BioPlex

SLC1A1

Tchem

Family:  Transporter

Novelty:  0.00218479

p_int:  0.964962043

p_ni:  0.035037545

p_wrong:  4.12e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (24)

Functions (4)

Components (10)

Processes (10)

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1 – 4 of 4

GO Term	Evidence	Assigned by
low-density lipoprotein particle receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
phosphatidylinositol binding	Inferred from Direct Assay (IDA)	UniProtKB
protein C-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB
signaling receptor binding	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (27)

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5

1 – 5 of 27

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	9	16	27		99.9
C-reactive protein measurement	EFO_0004458	1	5	5		97.8
total cholesterol measurement	EFO_0004574	3	6	4	3.9	96.5
serum gamma-glutamyl transferase measurement	EFO_0004532	1	4	4		96
apolipoprotein B measurement	EFO_0004615	1	5	5		95.5

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5

1 – 5 of 27

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	27		99.9
C-reactive protein measurement	EFO_0004458	5		97.8
total cholesterol measurement	EFO_0004574	4	3.9	96.5
serum gamma-glutamyl transferase measurement	EFO_0004532	4		96
apolipoprotein B measurement	EFO_0004615	5		95.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Endosome
Lipid-binding
Membrane
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
albuminuria
apolipoprotein A 1 measurement
apolipoprotein B measurement
appendicular lean mass
blood protein measurement
C-reactive protein measurement
calcium measurement
creatinine measurement
Crohn's disease
glomerular filtration rate

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	sorting nexin 17	VGNC:392	459100
Macaque	sorting nexin 17		701614
Mouse	sorting nexin 17	MGI:2387801	266781
Rat	sorting nexin 17	RGD:1306424	298836
Dog	sorting nexin 17	VGNC:46626	483011

Species	Name	OMA	EggNOG	Inparanoid
Chimp	sorting nexin 17
Macaque	sorting nexin 17
Mouse	sorting nexin 17
Rat	sorting nexin 17
Dog	sorting nexin 17

Publication Statistics

PubMed Score 28.55

PubMed score by year

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PubTator Score 21.00

PubTator score by year

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Related Publications

Text Mined References (35)

GeneRif Annotations (11)

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PMID	Year	Title