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Tbio
SNX17
Sorting nexin-17

Protein Summary
Description
Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233575
  • ENSP00000233575
  • ENSG00000115234
  • ENST00000537606
  • ENSP00000439208

Symbol
  • KIAA0064
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
transcription factor binding site profile
0.9
histone modification site profile
0.88
kinase perturbation
0.88
cell type or tissue
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.55   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.55   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
RHEX
Tbio
Novelty:  0.20957256
p_int:  0.999999952
p_ni:  4.8e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.999998845
p_ni:  0.000001155
Data Source:  BioPlex
COPZ2
Tdark
Novelty:  0.21561497
p_int:  0.995390637
p_ni:  0.004609363
Data Source:  BioPlex
PITRM1
Tchem
Family:  Enzyme
Novelty:  0.08067518
p_int:  0.989544059
p_ni:  0.010455941
Data Source:  BioPlex
NPDC1
Tbio
Novelty:  0.05766647
p_int:  0.986022022
p_ni:  0.013977978
Score:  0.201
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.981779798
p_ni:  0.018219135
p_wrong:  0.000001068
Data Source:  BioPlex
GMPR2
Tbio
Family:  Enzyme
Novelty:  0.16707153
p_int:  0.97768339
p_ni:  0.022316582
p_wrong:  2.7e-8
Score:  0.529
Data Source:  BioPlex,STRINGDB
MTM1
Tbio
Family:  Enzyme
Novelty:  0.00413329
p_int:  0.977387115
p_ni:  0.022612885
Score:  0.234
Data Source:  BioPlex,STRINGDB
IL20RA
Tbio
Novelty:  0.02416816
p_int:  0.968132301
p_ni:  0.031867699
Data Source:  BioPlex
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
p_int:  0.964962043
p_ni:  0.035037545
p_wrong:  4.12e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
16
27
99.9
C-reactive protein measurement
1
5
5
97.8
total cholesterol measurement
3
6
4
3.9
96.5
serum gamma-glutamyl transferase measurement
1
4
4
96
apolipoprotein B measurement
1
5
5
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
27
99.9
C-reactive protein measurement
5
97.8
total cholesterol measurement
4
3.9
96.5
serum gamma-glutamyl transferase measurement
4
96
apolipoprotein B measurement
5
95.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 17
VGNC:392
459100
Macaque
sorting nexin 17
701614
Mouse
MGI:2387801
266781
Rat
RGD:1306424
298836
Dog
sorting nexin 17
VGNC:46626
483011
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 17
Macaque
sorting nexin 17
Mouse
Rat
Dog
sorting nexin 17
Publication Statistics
PubMed Score 28.55
PubMed score by year
PubTator Score 21.00
PubTator score by year
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Related Publications
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PMID
Year
Title