Protein Summary
Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing ...more
- ENST00000233575
- ENSP00000233575
- ENSG00000115234
- ENST00000537606
- ENSP00000439208
- KIAA0064
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.93 | ||
transcription factor binding site profile | 0.9 | ||
histone modification site profile | 0.88 | ||
kinase perturbation | 0.88 | ||
cell type or tissue | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.55 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 142 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.55 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 142 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (98)
RHEX
Novelty: 0.20957256
p_int: 0.999999952
p_ni: 4.8e-8
Score: 0.186
Data Source: BioPlex,STRINGDB
VIPR2
Family: GPCR
Novelty: 0.00463802
p_int: 0.999998845
p_ni: 0.000001155
Data Source: BioPlex
PITRM1
Family: Enzyme
Novelty: 0.08067518
p_int: 0.989544059
p_ni: 0.010455941
Data Source: BioPlex
NPDC1
Novelty: 0.05766647
p_int: 0.986022022
p_ni: 0.013977978
Score: 0.201
Data Source: BioPlex,STRINGDB
MANSC1
Novelty: 0.91681036
p_int: 0.981779798
p_ni: 0.018219135
p_wrong: 0.000001068
Data Source: BioPlex
GMPR2
Family: Enzyme
Novelty: 0.16707153
p_int: 0.97768339
p_ni: 0.022316582
p_wrong: 2.7e-8
Score: 0.529
Data Source: BioPlex,STRINGDB
MTM1
Family: Enzyme
Novelty: 0.00413329
p_int: 0.977387115
p_ni: 0.022612885
Score: 0.234
Data Source: BioPlex,STRINGDB
SLC1A1
Family: Transporter
Novelty: 0.00218479
p_int: 0.964962043
p_ni: 0.035037545
p_wrong: 4.12e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (4)
Components (10)
Processes (10)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (27)
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 9 | 16 | 27 | 99.9 | |||||
C-reactive protein measurement | 1 | 5 | 5 | 97.8 | |||||
total cholesterol measurement | 3 | 6 | 4 | 3.9 | 96.5 | ||||
serum gamma-glutamyl transferase measurement | 1 | 4 | 4 | 96 | |||||
apolipoprotein B measurement | 1 | 5 | 5 | 95.5 | |||||
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
triglyceride measurement | 27 | 99.9 | |||||
C-reactive protein measurement | 5 | 97.8 | |||||
total cholesterol measurement | 4 | 3.9 | 96.5 | ||||
serum gamma-glutamyl transferase measurement | 4 | 96 | |||||
apolipoprotein B measurement | 5 | 95.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | sorting nexin 17 | VGNC:392 | 459100 | |||||
Macaque | sorting nexin 17 | 701614 | ||||||
Mouse | MGI:2387801 | 266781 | ||||||
Rat | RGD:1306424 | 298836 | ||||||
Dog | sorting nexin 17 | VGNC:46626 | 483011 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | sorting nexin 17 | |||||
Macaque | sorting nexin 17 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sorting nexin 17 | |||||
Publication Statistics
PubMed Score 28.55
PubMed score by year
PubTator Score 21.00
PubTator score by year
Related Publications
Text Mined References (35)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
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