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Tbio
SNX16
Sorting nexin-16

Protein Summary
Description
May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The protein encoded by this gene associates with late endosome membranes as is involved in tubule formation, cholesterol transport, and transport of tetraspanin CD81. The encoded protein also inhibits cell migration and tumorigenesis. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345957
  • ENSP00000322652
  • ENSG00000104497
  • ENST00000353788
  • ENSP00000322631
  • ENST00000396330
  • ENSP00000379621
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
histone modification site profile
0.92
microRNA
0.79
transcription factor
0.75
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.13   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.13   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
YEATS4
Tbio
Novelty:  0.02632024
p_int:  0.999999454
p_ni:  5.42e-7
p_wrong:  3e-9
Score:  0.224
Data Source:  BioPlex,STRINGDB
KIF6
Tbio
Novelty:  0.02486302
p_int:  0.999999451
p_ni:  4.1e-8
p_wrong:  5.09e-7
Score:  0.466
Data Source:  BioPlex,STRINGDB
TBC1D2B
Tdark
Novelty:  0.52348266
p_int:  0.998266303
p_ni:  0.001733697
Data Source:  BioPlex
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.995533048
p_ni:  0.004466952
Data Source:  BioPlex
GNAO1
Tbio
Novelty:  0.00315097
p_int:  0.846687594
p_ni:  0.153311838
p_wrong:  5.67e-7
Score:  0.182
Data Source:  BioPlex,STRINGDB
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
p_int:  0.805417939
p_ni:  0.194581816
p_wrong:  2.45e-7
Data Source:  BioPlex
PALM
Tbio
Novelty:  0.04984456
p_int:  0.792825249
p_ni:  0.207174748
p_wrong:  3e-9
Data Source:  BioPlex
FCHSD1
Tdark
Novelty:  0.53501769
Score:  0.736
Data Source:  STRINGDB
NAALAD2
Tchem
Family:  Enzyme
Novelty:  0.18444329
Score:  0.714
Data Source:  STRINGDB
CCDC85B
Tdark
Novelty:  0.02034018
Score:  0.689
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
2
0
1.1
86.8
1
1
0
1.2
37.6
age-related hearing impairment
1
1
0
5.6
21.5
mean platelet volume
1
1
1
12.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
86.8
0
1.2
37.6
age-related hearing impairment
0
5.6
21.5
mean platelet volume
1
12.3
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 16
VGNC:795
464258
Macaque
sorting nexin 16
702409
Mouse
MGI:1921968
74718
Rat
RGD:620295
64088
Dog
sorting nexin 16
VGNC:46625
487019
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 16
Macaque
sorting nexin 16
Mouse
Rat
Dog
sorting nexin 16
Publication Statistics
PubMed Score 9.13
PubMed score by year
PubTator Score 6.69
PubTator score by year
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Related Publications
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PMID
Year
Title