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Tdark
SNX15
Sorting nexin-15

Protein Summary
Description
May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352068
  • ENSP00000316410
  • ENSG00000110025
  • ENST00000377244
  • ENSP00000366452

Symbol
  • HSAF001435
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
cellular component
0.73
interacting protein
0.71
transcription factor binding site profile
0.7
cell type or tissue
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.48   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.48   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
HOXC10
Tbio
Family:  TF
Novelty:  0.02817778
p_int:  0.999999801
p_ni:  1.99e-7
p_wrong:  1e-9
Score:  0.54
Data Source:  BioPlex,STRINGDB
NT5C2
Tbio
Family:  Enzyme
Novelty:  0.00758288
p_int:  0.999999795
p_ni:  2.05e-7
Score:  0.692
Data Source:  BioPlex,STRINGDB
ANXA7
Tbio
Novelty:  0.00365221
Score:  0.71
Data Source:  STRINGDB
FIP1L1
Tbio
Novelty:  0.00520044
Score:  0.648
Data Source:  STRINGDB
CCDC106
Tdark
Novelty:  0.7081207
Score:  0.63
Data Source:  STRINGDB
SNX4
Tbio
Novelty:  0.05441145
Score:  0.626
Data Source:  STRINGDB
RBM7
Tbio
Novelty:  0.07482689
Score:  0.617
Data Source:  STRINGDB
SNX33
Tbio
Novelty:  0.11762505
Score:  0.605
Data Source:  STRINGDB
RNF150
Tdark
Novelty:  0.49393737
Score:  0.596
Data Source:  STRINGDB
SPAST
Tbio
Novelty:  0.00303236
Score:  0.592
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
2
2
87.4
uric acid measurement
1
1
1
69
high density lipoprotein cholesterol measurement
1
1
1
48.5
1
1
0
1.9
13.9
metabolic syndrome
1
1
1
8.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
87.4
uric acid measurement
1
69
high density lipoprotein cholesterol measurement
1
48.5
0
1.9
13.9
metabolic syndrome
1
8.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 15
VGNC:1003
451307
Mouse
MGI:1916274
69024
Rat
RGD:1305803
293691
Dog
sorting nexin 15
VGNC:46624
612080
Horse
sorting nexin 15
VGNC:23414
100050811
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 15
Mouse
Rat
Dog
sorting nexin 15
Horse
sorting nexin 15
Publication Statistics
PubMed Score 4.48
PubMed score by year
PubTator Score 4.33
PubTator score by year
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Related Publications
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PMID
Year
Title