Tbio SNX14 Sorting nexin-14

Protein Summary

Description

Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes (PubMed:25848753). Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:25848753, PubMed:25148684). This gene encodes a member of the sorting nexin family. Members of this family have a phox (PX) phosphoinositide binding domain and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Alternate splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q9Y5W7
• B4DI55
• Q4VBR3
• Q5TCF9
• Q5TCG0
• Q6NUI7
• Q6PI37
• Q9BSD1

Gene Name

• SNX14

Ensembl ID

• ENST00000314673
• ENSP00000313121
• ENSG00000135317
• ENST00000346348
• ENSP00000257769
• ENST00000369627
• ENSP00000358641
• ENST00000505648
• ENSP00000427380

Symbol

• SCAR20
• RGS-PX2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
interacting protein	0.85
transcription factor binding site profile	0.83
tissue sample	0.68
cell line	0.62

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Sorting Nexin-14

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Sorting Nexin-14

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.09   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 73   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.09   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0