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Tbio
SNX14
Sorting nexin-14

Protein Summary
Description
Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes (PubMed:25848753). Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:25848753, PubMed:25148684). This gene encodes a member of the sorting nexin family. Members of this family have a phox (PX) phosphoinositide binding domain and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Alternate splicing results in transcript variants encoding distinct isoforms. [ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314673
  • ENSP00000313121
  • ENSG00000135317
  • ENST00000346348
  • ENSP00000257769
  • ENST00000369627
  • ENSP00000358641
  • ENST00000505648
  • ENSP00000427380

Symbol
  • SCAR20
  • RGS-PX2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
interacting protein
0.85
transcription factor binding site profile
0.83
tissue sample
0.68
cell line
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.09   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.09   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
TSPAN2
Tbio
Novelty:  0.03842973
p_int:  0.999998088
p_ni:  0.000001911
p_wrong:  1e-9
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.998087304
p_ni:  0.001912696
Data Source:  BioPlex
ANKRD9
Tdark
Novelty:  0.43181793
p_int:  0.997241142
p_ni:  0.002758776
p_wrong:  8.2e-8
Data Source:  BioPlex
CNGA3
Tchem
Family:  IC
Novelty:  0.00818181
p_int:  0.99448275
p_ni:  0.005517077
p_wrong:  1.73e-7
Score:  0.151
Data Source:  BioPlex,STRINGDB
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.993824357
p_ni:  0.0061614
p_wrong:  0.000014242
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.9925715
p_ni:  0.007428498
p_wrong:  2e-9
Data Source:  BioPlex
SLC4A8
Tbio
Family:  Transporter
Novelty:  0.01606111
p_int:  0.992428443
p_ni:  0.007571548
p_wrong:  9e-9
Data Source:  BioPlex
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.991448161
p_ni:  0.00855183
p_wrong:  9e-9
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.990759842
p_ni:  0.009233273
p_wrong:  0.000006886
Data Source:  BioPlex
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.989399787
p_ni:  0.010600179
p_wrong:  3.4e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
27.4
blood metabolite measurement
1
1
1
16.4
neutrophil count
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
27.4
blood metabolite measurement
1
16.4
neutrophil count
1
1.8
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 14
VGNC:3705
462865
Macaque
sorting nexin 14
696632
Mouse
MGI:2155664
244962
Rat
RGD:1310921
315871
Dog
sorting nexin 14
VGNC:46623
474985
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 14
Macaque
sorting nexin 14
Mouse
Rat
Dog
sorting nexin 14
Publication Statistics
PubMed Score 19.09
PubMed score by year
PubTator Score 7.72
PubTator score by year
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Related Publications
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PMID
Year
Title