Protein Summary
May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas. This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]
- ENST00000428135
- ENSP00000398789
- ENSG00000071189
- KIAA0713
- RGS-PX1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.85 | ||
histone modification site profile | 0.81 | ||
transcription factor perturbation | 0.8 | ||
transcription factor binding site profile | 0.79 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.8 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 82 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.8 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 82 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (62)
TSPAN2
Novelty: 0.03842973
p_int: 0.999999989
p_ni: 1.1e-8
Score: 0.235
Data Source: BioPlex,STRINGDB
TSPAN1
Novelty: 0.01547855
p_int: 0.999996191
p_ni: 0.000003801
p_wrong: 9e-9
Data Source: BioPlex
IPPK
Family: Enzyme
Novelty: 0.02169701
p_int: 0.994917991
p_ni: 0.000066081
p_wrong: 0.005015928
Score: 0.173
Data Source: BioPlex,STRINGDB
TPRA1
Family: GPCR
Novelty: 0.16743826
p_int: 0.983479558
p_ni: 0.001547945
p_wrong: 0.014972497
Score: 0.188
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | GO_Central | |||
Disease Associations ()
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 9 | 6 | 13 | 97.2 | |||||
red blood cell distribution width | 3 | 4 | 4 | 95.3 | |||||
apolipoprotein A 1 measurement | 2 | 2 | 2 | 91.7 | |||||
aspartate aminotransferase measurement | 1 | 1 | 0 | 10.4 | 76.9 | ||||
triglyceride measurement | 3 | 3 | 3 | 74.1 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 13 | 97.2 | |||||
red blood cell distribution width | 4 | 95.3 | |||||
apolipoprotein A 1 measurement | 2 | 91.7 | |||||
aspartate aminotransferase measurement | 0 | 10.4 | 76.9 | ||||
triglyceride measurement | 3 | 74.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | sorting nexin 13 | VGNC:4512 | 463279 | |||||
Macaque | sorting nexin 13 | 714019 | ||||||
Mouse | MGI:2661416 | 217463 | ||||||
Rat | RGD:1309778 | 362731 | ||||||
Dog | sorting nexin 13 | VGNC:46622 | 475252 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | sorting nexin 13 | |||||
Macaque | sorting nexin 13 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sorting nexin 13 | |||||
Publication Statistics
PubMed Score 7.80
PubMed score by year
PubTator Score 4.65
PubTator score by year
Related Publications
Text Mined References (13)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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