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Tbio
SNX13
Sorting nexin-13

Protein Summary
Description
May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas. This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000428135
  • ENSP00000398789
  • ENSG00000071189

Symbol
  • KIAA0713
  • RGS-PX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.85
histone modification site profile
0.81
transcription factor perturbation
0.8
transcription factor binding site profile
0.79
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.8   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.8   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
TSPAN2
Tbio
Novelty:  0.03842973
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.235
Data Source:  BioPlex,STRINGDB
TSPAN1
Tbio
Novelty:  0.01547855
p_int:  0.999996191
p_ni:  0.000003801
p_wrong:  9e-9
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.994917991
p_ni:  0.000066081
p_wrong:  0.005015928
Score:  0.173
Data Source:  BioPlex,STRINGDB
TPRA1
Tdark
Family:  GPCR
Novelty:  0.16743826
p_int:  0.983479558
p_ni:  0.001547945
p_wrong:  0.014972497
Score:  0.188
Data Source:  BioPlex,STRINGDB
BZW2
Tbio
Novelty:  0.17006204
Score:  0.825
Data Source:  STRINGDB
ANKMY2
Tdark
Novelty:  0.50777631
Score:  0.815
Data Source:  STRINGDB
RPP25L
Tdark
Family:  Enzyme
Novelty:  1.39761189
Score:  0.806
Data Source:  STRINGDB
FERD3L
Tbio
Family:  TF
Novelty:  0.06797434
Score:  0.794
Data Source:  STRINGDB
ANXA7
Tbio
Novelty:  0.00365221
Score:  0.754
Data Source:  STRINGDB
HEPACAM2
Tbio
Novelty:  0.19192547
Score:  0.736
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
9
6
13
97.2
red blood cell distribution width
3
4
4
95.3
apolipoprotein A 1 measurement
2
2
2
91.7
aspartate aminotransferase measurement
1
1
0
10.4
76.9
triglyceride measurement
3
3
3
74.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
13
97.2
red blood cell distribution width
4
95.3
apolipoprotein A 1 measurement
2
91.7
aspartate aminotransferase measurement
0
10.4
76.9
triglyceride measurement
3
74.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 13
VGNC:4512
463279
Macaque
sorting nexin 13
714019
Mouse
MGI:2661416
217463
Rat
RGD:1309778
362731
Dog
sorting nexin 13
VGNC:46622
475252
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 13
Macaque
sorting nexin 13
Mouse
Rat
Dog
sorting nexin 13
Publication Statistics
PubMed Score 7.80
PubMed score by year
PubTator Score 4.65
PubTator score by year
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Related Publications
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PMID
Year
Title