Tbio SNX12 Sorting nexin-12

Protein Summary

Description

May be involved in several stages of intracellular trafficking. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. A similar protein in mouse may be involved in regulating the neurite outgrowth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• Q9UMY4
• F8W8K5
• Q8WUG9

Gene Name

• SNX12

Ensembl ID

• ENST00000276105
• ENSP00000276105
• ENSG00000147164
• ENST00000374274
• ENSP00000363392
• ENST00000622277
• ENSP00000481314

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.98
cell type or tissue	0.69
cellular component	0.62
kinase perturbation	0.6
transcription factor perturbation	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.54   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.54   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0