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Tdark
SNX11
Sorting nexin-11

Protein Summary
Description
Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359238
  • ENSP00000352175
  • ENSG00000002919
  • ENST00000393405
  • ENSP00000377059
  • ENST00000580219
  • ENSP00000462188
  • ENST00000582104
  • ENSP00000463948
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
disease perturbation
0.74
transcription factor
0.74
tissue sample
0.64
tissue
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.6   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.6   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
NPHP3
Tbio
Novelty:  0.02857926
p_int:  0.999999961
p_ni:  3.9e-8
Score:  0.193
Data Source:  BioPlex,STRINGDB
ORC3
Tbio
Novelty:  0.03409802
p_int:  0.999879672
p_ni:  0.000006301
p_wrong:  0.000114027
Score:  0.228
Data Source:  BioPlex,STRINGDB
PML
Tbio
Novelty:  0.00285474
p_int:  0.998194592
p_ni:  0.001805408
Score:  0.193
Data Source:  BioPlex,STRINGDB
FGFR3
Tclin
Family:  Kinase
Novelty:  0.00071612
p_int:  0.996716055
p_ni:  0.003282312
p_wrong:  0.000001633
Score:  0.228
Data Source:  BioPlex,STRINGDB
STK40
Tbio
Family:  Kinase
Novelty:  0.10461675
p_int:  0.994109905
p_ni:  0.005886985
p_wrong:  0.000003109
Score:  0.201
Data Source:  BioPlex,STRINGDB
DCAF10
Tdark
Novelty:  2.6713128
p_int:  0.983851885
p_ni:  0.016148115
Score:  0.161
Data Source:  BioPlex,STRINGDB
TNFRSF9
Tbio
Novelty:  0.00162382
p_int:  0.974884831
p_ni:  0.025115168
Score:  0.187
Data Source:  BioPlex,STRINGDB
PNPLA4
Tbio
Family:  Enzyme
Novelty:  0.07471752
p_int:  0.894500489
p_ni:  0.105480035
p_wrong:  0.000019476
Score:  0.221
Data Source:  BioPlex,STRINGDB
MRPL16
Tdark
Novelty:  0.38562971
p_int:  0.86603368
p_ni:  0.133910986
p_wrong:  0.000055334
Data Source:  BioPlex
SUSD3
Tdark
Novelty:  0.43699506
p_int:  0.86603368
p_ni:  0.133910986
p_wrong:  0.000055334
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
2
4
88.7
heel bone mineral density
2
3
3
77
triglyceride measurement
3
2
3
75.4
hemoglobin measurement
1
1
1
72.9
BMI-adjusted hip circumference
2
2
3
66.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
88.7
heel bone mineral density
3
77
triglyceride measurement
3
75.4
hemoglobin measurement
1
72.9
BMI-adjusted hip circumference
3
66.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 11
VGNC:9640
455186
Macaque
sorting nexin 11
696913
Mouse
MGI:1921729
74479
Rat
RGD:1307319
303493
Dog
sorting nexin 11
VGNC:46621
480542
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 11
Macaque
sorting nexin 11
Mouse
Rat
Dog
sorting nexin 11
Publication Statistics
PubMed Score 4.60
PubMed score by year
PubTator Score 1.70
PubTator score by year
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Related Publications
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PMID
Year
Title