Protein Summary
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocyt ...more
- ENST00000261889
- ENSP00000261889
- ENSG00000028528
- ENST00000559844
- ENSP00000453785
- ENST00000561026
- ENSP00000453567
- VPS5
- HsT17379
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 0.97 | ||
interacting protein | 0.89 | ||
transcription factor perturbation | 0.88 | ||
transcription factor binding site profile | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 91.82 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 337 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 91.82 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 337 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (137)
SNX5
Novelty: 0.04075649
p_int: 0.999999997
p_ni: 3e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
SNX6
Novelty: 0.05909848
p_int: 0.999999953
p_ni: 4.3e-8
p_wrong: 4e-9
Score: 0.991
Data Source: BioPlex,STRINGDB
BIN3
Novelty: 0.02034119
p_int: 0.999999939
p_ni: 6.1e-8
Score: 0.336
Data Source: BioPlex,STRINGDB
SNX2
Novelty: 0.03880384
p_int: 0.999997789
p_ni: 0.000002211
Score: 0.976
Data Source: BioPlex,STRINGDB
C1orf87
Novelty: 0.03162594
p_int: 0.999995777
p_ni: 0.000004223
Score: 0.538
Data Source: BioPlex,STRINGDB
HYOU1
Novelty: 0.00833649
p_int: 0.999752857
p_ni: 0.000247142
p_wrong: 1e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
KEGG (1)
PathwayCommons (3)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Endocytosis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Endocytosis | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (9)
Components (14)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 1 | 1 | 64.9 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 49.5 | |||||
apolipoprotein B measurement | 1 | 1 | 1 | 35 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 64.9 | |||||
monocyte percentage of leukocytes | 1 | 49.5 | |||||
apolipoprotein B measurement | 1 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | sorting nexin 1 | VGNC:1875 | 453503 | |||||
Macaque | sorting nexin 1 | 706544 | ||||||
Mouse | MGI:1928395 | 56440 | ||||||
Rat | RGD:68935 | 84471 | ||||||
Dog | sorting nexin 1 | VGNC:46619 | 478336 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | sorting nexin 1 | |||||
Macaque | sorting nexin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sorting nexin 1 | |||||
Publication Statistics
PubMed Score 91.82
PubMed score by year
PubTator Score 41.74
PubTator score by year
Related Publications
Text Mined References (53)
GeneRif Annotations (23)
Items per page:
0 of 0
PMID | Year | Title |
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