Protein Summary
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
- ENST00000308588
- ENSP00000309831
- ENSG00000169371
- ENST00000564644
- ENSP00000454852
- ENST00000564675
- ENSP00000458053
- ENST00000567134
- ENSP00000456224
- RNUT1
- SPN1
- KPNBL
- RNUT1
- Snurportin1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.98 | ||
transcription factor binding site profile | 0.79 | ||
interacting protein | 0.77 | ||
tissue sample | 0.7 | ||
histone modification site profile | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.22 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 178 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.22 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 178 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (101)
SNRPB2
Novelty: 0.17219587
p_int: 0.999972153
p_ni: 0.000027287
p_wrong: 5.6e-7
Score: 0.196
Data Source: BioPlex,STRINGDB
SNRPA1
Novelty: 0.01232044
p_int: 0.999909791
p_ni: 0.000090209
Score: 0.744
Data Source: BioPlex,STRINGDB
PDP1
Family: Enzyme
Novelty: 0.00442352
p_int: 0.999563548
p_ni: 0.000436452
Score: 0.29
Data Source: BioPlex,STRINGDB
SNRPE
Novelty: 0.02033423
p_int: 0.998418216
p_ni: 0.001581784
Score: 0.967
Data Source: BioPlex,STRINGDB
SNRPN
Novelty: 0.002157
p_int: 0.989614676
p_ni: 0.01030817
p_wrong: 0.000077154
Score: 0.626
Data Source: BioPlex,STRINGDB
TOE1
Novelty: 0.03660884
p_int: 0.97555527
p_ni: 0.02444473
Score: 0.858
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Metabolism of RNA | ||||
Reactome | Metabolism of non-coding RNA | ||||
Reactome | snRNP Assembly | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Metabolism of RNA | ||||
Metabolism of non-coding RNA | ||||
snRNP Assembly | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body height | 2 | 2 | 2 | 91.6 | |||||
3 | 2 | 2 | 1.1 | 86.6 | |||||
creatinine measurement | 1 | 4 | 4 | 73.1 | |||||
glomerular filtration rate | 1 | 4 | 4 | 70.9 | |||||
testosterone measurement | 2 | 1 | 2 | 64 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body height | 2 | 91.6 | |||||
2 | 1.1 | 86.6 | |||||
creatinine measurement | 4 | 73.1 | |||||
glomerular filtration rate | 4 | 70.9 | |||||
testosterone measurement | 2 | 64 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:1913319 | 66069 | ||||||
Rat | RGD:1303191 | 316108 | ||||||
Dog | snurportin 1 | VGNC:46618 | 487655 | |||||
Horse | snurportin 1 | VGNC:51420 | 100051100 | |||||
Cow | snurportin 1 | VGNC:35088 | 515588 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | snurportin 1 | |||||
Horse | snurportin 1 | |||||
Cow | snurportin 1 | |||||
Publication Statistics
PubMed Score 22.22
PubMed score by year
PubTator Score 21.23
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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