Tbio SNUPN Snurportin-1

Protein Summary

Description

Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95149
• A6NE34
• A8K0B0
• D3DW76

Gene Name

• SNUPN

Ensembl ID

• ENST00000308588
• ENSP00000309831
• ENSG00000169371
• ENST00000564644
• ENSP00000454852
• ENST00000564675
• ENSP00000458053
• ENST00000567134
• ENSP00000456224

Symbol

• RNUT1
• SPN1
• KPNBL
• RNUT1
• Snurportin1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
transcription factor binding site profile	0.79
interacting protein	0.77
tissue sample	0.7
histone modification site profile	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.22   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.22   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (101)

Explore Interacting Targets

1 – 10 of 101

• See Interactions on String-DB

SNRPB2

Tbio

Novelty:  0.17219587

p_int:  0.999972153

p_ni:  0.000027287

p_wrong:  5.6e-7

Score:  0.196

Data Source:  BioPlex,STRINGDB

SNRPA1

Tbio

Novelty:  0.01232044

p_int:  0.999909791

p_ni:  0.000090209

Score:  0.744

Data Source:  BioPlex,STRINGDB

PDP1

Tbio

Family:  Enzyme

Novelty:  0.00442352

p_int:  0.999563548

p_ni:  0.000436452

Score:  0.29

Data Source:  BioPlex,STRINGDB

SNRPE

Tbio

Novelty:  0.02033423

p_int:  0.998418216

p_ni:  0.001581784

Score:  0.967

Data Source:  BioPlex,STRINGDB

SNRPN

Tbio

Novelty:  0.002157

p_int:  0.989614676

p_ni:  0.01030817

p_wrong:  0.000077154

Score:  0.626

Data Source:  BioPlex,STRINGDB

TOE1

Tbio

Novelty:  0.03660884

p_int:  0.97555527

p_ni:  0.02444473

Score:  0.858

Data Source:  BioPlex,STRINGDB

KPNB1

Tbio

Novelty:  0.01469696

Score:  0.993

Data Source:  STRINGDB

XPO1

Tclin

Novelty:  0.00078187

Score:  0.992

Data Source:  STRINGDB

SNRPD1

Tbio

Novelty:  0.0136355

Score:  0.991

Data Source:  STRINGDB

DDX20

Tbio

Family:  Enzyme

Novelty:  0.01854078

Score:  0.966

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Metabolism of RNA (R-HSA-8953854)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Metabolism of non-coding RNA	53 targets	R-HSA-194441
Reactome	snRNP Assembly	53 targets	R-HSA-191859

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
Metabolism of non-coding RNA	53 targets	R-HSA-194441
snRNP Assembly	53 targets	R-HSA-191859

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (2)

Components (2)

Processes (4)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
RNA cap binding	Traceable Author Statement (TAS)	ProtInc
nuclear import signal receptor activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (11)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 11

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	2	2	2		91.6
type II diabetes mellitus	EFO_0001360	3	2	2	1.1	86.6
creatinine measurement	EFO_0004518	1	4	4		73.1
glomerular filtration rate	EFO_0005208	1	4	4		70.9
testosterone measurement	EFO_0004908	2	1	2		64

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 11

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	2		91.6
type II diabetes mellitus	EFO_0001360	2	1.1	86.6
creatinine measurement	EFO_0004518	4		73.1
glomerular filtration rate	EFO_0005208	4		70.9
testosterone measurement	EFO_0004908	2		64

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Nucleus
Phosphoprotein
Reference proteome
RNA-binding
Transport

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
body height
creatinine measurement
glomerular filtration rate
hip circumference
intraocular pressure measurement
serum urea measurement
sex hormone-binding globulin measurement
testosterone measurement
type II diabetes mellitus

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	snurportin 1	MGI:1913319	66069
Rat	snurportin 1	RGD:1303191	316108
Dog	snurportin 1	VGNC:46618	487655
Horse	snurportin 1	VGNC:51420	100051100
Cow	snurportin 1	VGNC:35088	515588

Species	Name	OMA	EggNOG	Inparanoid
Mouse	snurportin 1
Rat	snurportin 1
Dog	snurportin 1
Horse	snurportin 1
Cow	snurportin 1

Publication Statistics

PubMed Score 22.22

PubMed score by year

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PubTator Score 21.23

PubTator score by year

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Related Publications

Text Mined References (21)

GeneRif Annotations (6)

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10

0 of 0

PMID	Year	Title