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Tbio
SNUPN
Snurportin-1

Protein Summary
Description
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308588
  • ENSP00000309831
  • ENSG00000169371
  • ENST00000564644
  • ENSP00000454852
  • ENST00000564675
  • ENSP00000458053
  • ENST00000567134
  • ENSP00000456224

Symbol
  • RNUT1
  • SPN1
  • KPNBL
  • RNUT1
  • Snurportin1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor binding site profile
0.79
interacting protein
0.77
tissue sample
0.7
histone modification site profile
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.46   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.46   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
SNRPB2
Tbio
Novelty:  0.17219587
p_int:  0.999972153
p_ni:  0.000027287
p_wrong:  5.6e-7
Score:  0.196
Data Source:  BioPlex,STRINGDB
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.999909791
p_ni:  0.000090209
Score:  0.744
Data Source:  BioPlex,STRINGDB
PDP1
Tbio
Family:  Enzyme
Novelty:  0.00442352
p_int:  0.999563548
p_ni:  0.000436452
Score:  0.29
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.998418216
p_ni:  0.001581784
Score:  0.967
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.989614676
p_ni:  0.01030817
p_wrong:  0.000077154
Score:  0.626
Data Source:  BioPlex,STRINGDB
TOE1
Tbio
Novelty:  0.03660884
p_int:  0.97555527
p_ni:  0.02444473
Score:  0.858
Data Source:  BioPlex,STRINGDB
KPNB1
Tbio
Novelty:  0.01469696
Score:  0.993
Data Source:  STRINGDB
XPO1
Tclin
Novelty:  0.00078187
Score:  0.992
Data Source:  STRINGDB
SNRPD1
Tbio
Novelty:  0.0136355
Score:  0.991
Data Source:  STRINGDB
DDX20
Tbio
Family:  Enzyme
Novelty:  0.01854078
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
snRNP Assembly
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of non-coding RNA
snRNP Assembly
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
93.6
type 2 diabetes mellitus
3
2
2
1.1
89.4
testosterone measurement
2
1
2
67.2
creatinine measurement
1
4
4
64
glomerular filtration rate
1
4
4
61.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
93.6
type 2 diabetes mellitus
2
1.1
89.4
testosterone measurement
2
67.2
creatinine measurement
4
64
glomerular filtration rate
4
61.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913319
66069
Rat
RGD:1303191
316108
Dog
snurportin 1
VGNC:46618
487655
Horse
snurportin 1
VGNC:51420
100051100
Cow
snurportin 1
VGNC:35088
515588
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
snurportin 1
Horse
snurportin 1
Cow
snurportin 1
Publication Statistics
PubMed Score 23.46
PubMed score by year
PubTator Score 21.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title