Protein Summary
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
- ENST00000308588
- ENSP00000309831
- ENSG00000169371
- ENST00000564644
- ENSP00000454852
- ENST00000564675
- ENSP00000458053
- ENST00000567134
- ENSP00000456224
- RNUT1
- SPN1
- KPNBL
- RNUT1
- Snurportin1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.98 | ||
transcription factor binding site profile | 0.79 | ||
interacting protein | 0.77 | ||
tissue sample | 0.7 | ||
histone modification site profile | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.46 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 178 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.46 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 178 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (101)
SNRPB2
Novelty: 0.17219587
p_int: 0.999972153
p_ni: 0.000027287
p_wrong: 5.6e-7
Score: 0.196
Data Source: BioPlex,STRINGDB
SNRPA1
Novelty: 0.01232044
p_int: 0.999909791
p_ni: 0.000090209
Score: 0.744
Data Source: BioPlex,STRINGDB
PDP1
Family: Enzyme
Novelty: 0.00442352
p_int: 0.999563548
p_ni: 0.000436452
Score: 0.29
Data Source: BioPlex,STRINGDB
SNRPE
Novelty: 0.02033423
p_int: 0.998418216
p_ni: 0.001581784
Score: 0.967
Data Source: BioPlex,STRINGDB
SNRPN
Novelty: 0.002157
p_int: 0.989614676
p_ni: 0.01030817
p_wrong: 0.000077154
Score: 0.626
Data Source: BioPlex,STRINGDB
TOE1
Novelty: 0.03660884
p_int: 0.97555527
p_ni: 0.02444473
Score: 0.858
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of RNA | ||||
Reactome | Metabolism of non-coding RNA | ||||
Reactome | snRNP Assembly | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of RNA | ||||
Metabolism of non-coding RNA | ||||
snRNP Assembly | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 2 | 2 | 2 | 93.6 | |||||
type 2 diabetes mellitus | 3 | 2 | 2 | 1.1 | 89.4 | ||||
testosterone measurement | 2 | 1 | 2 | 67.2 | |||||
creatinine measurement | 1 | 4 | 4 | 64 | |||||
glomerular filtration rate | 1 | 4 | 4 | 61.5 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 2 | 93.6 | |||||
type 2 diabetes mellitus | 2 | 1.1 | 89.4 | ||||
testosterone measurement | 2 | 67.2 | |||||
creatinine measurement | 4 | 64 | |||||
glomerular filtration rate | 4 | 61.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1913319 | 66069 | ||||||
Rat | RGD:1303191 | 316108 | ||||||
Dog | snurportin 1 | VGNC:46618 | 487655 | |||||
Horse | snurportin 1 | VGNC:51420 | 100051100 | |||||
Cow | snurportin 1 | VGNC:35088 | 515588 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | snurportin 1 | |||||
Horse | snurportin 1 | |||||
Cow | snurportin 1 | |||||
Publication Statistics
PubMed Score 23.46
PubMed score by year
PubTator Score 21.23
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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