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Tbio
SNTG2
Gamma-2-syntrophin

Protein Summary
Description
Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). This gene encodes a protein belonging to the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that bind to components of mechanosenstive sodium channels and the extreme carboxy-terminal domain of dystrophin and dystrophin-related proteins. The PDZ domain of this protein product interacts with a protein component of a mechanosensitive sodium channel that affects channel gating. Absence or reduction of this protein product has been associated with Duchenne muscular dystrophy. There is evidence of alternative splicing yet the full-length nature of these variants has not been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308624
  • ENSP00000311837
  • ENSG00000172554
  • ENST00000407292
  • ENSP00000385020

Symbol
  • SYN5
  • G2SYN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.64
gene perturbation
0.61
phenotype
0.61
histone modification site profile
0.56
cell line
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.1   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.1   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
DMD
Tclin
Novelty:  0.00025661
p_int:  1
Score:  0.989
Data Source:  BioPlex,STRINGDB
DTNB
Tbio
Novelty:  0.0586565
p_int:  0.999999996
p_ni:  4e-9
Score:  0.95
Data Source:  BioPlex,STRINGDB
SNTA1
Tbio
Novelty:  0.01668288
p_int:  0.99999999
p_ni:  7e-9
p_wrong:  3e-9
Score:  0.964
Data Source:  BioPlex,STRINGDB
CTNNAL1
Tbio
Novelty:  0.03667606
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.822
Data Source:  BioPlex,STRINGDB
SNTB1
Tbio
Novelty:  0.05324344
p_int:  0.999999985
p_ni:  3e-9
p_wrong:  1.3e-8
Score:  0.963
Data Source:  BioPlex,STRINGDB
DTNA
Tbio
Novelty:  0.01165754
p_int:  0.999999983
p_ni:  1.7e-8
Score:  0.9
Data Source:  BioPlex,STRINGDB
SNTB2
Tbio
Novelty:  0.05469501
p_int:  0.999999914
p_ni:  8.5e-8
p_wrong:  1e-9
Score:  0.94
Data Source:  BioPlex,STRINGDB
UTRN
Tchem
Novelty:  0.0018541
p_int:  0.999999646
p_ni:  3.54e-7
Score:  0.933
Data Source:  BioPlex,STRINGDB
EPSTI1
Tbio
Novelty:  0.07872736
p_int:  0.999993692
p_ni:  0.000003134
p_wrong:  0.000003174
Score:  0.209
Data Source:  BioPlex,STRINGDB
RNF31
Tbio
Family:  Enzyme
Novelty:  0.01394304
p_int:  0.996494659
p_ni:  0.003036264
p_wrong:  0.000469077
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid peroxidase antibody measurement
3
2
1
1.4
92.2
3
1
2
1.1
87.9
autoimmune thyroid disease
1
1
0
1.1
82.4
Thyroid preparation use measurement
2
1
2
68.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid peroxidase antibody measurement
1
1.4
92.2
2
1.1
87.9
autoimmune thyroid disease
0
1.1
82.4
Thyroid preparation use measurement
2
68.3
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntrophin gamma 2
VGNC:10769
742681
Macaque
syntrophin gamma 2
706376
Mouse
MGI:1919541
268534
Rat
RGD:1311276
298936
Dog
syntrophin gamma 2
VGNC:46616
607319
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntrophin gamma 2
Macaque
syntrophin gamma 2
Mouse
Rat
Dog
syntrophin gamma 2
Publication Statistics
PubMed Score 56.10
PubMed score by year
PubTator Score 23.43
PubTator score by year
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Related Publications
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PMID
Year
Title