Tbio SNTG1 Gamma-1-syntrophin

Protein Summary

Description

Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation. The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This family member plays a role in mediating gamma-enolase trafficking to the plasma membrane and in enhancing its neurotrophic activity. Mutations in this gene are associated with idiopathic scoliosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q9NSN8
• Q2M3Q0
• Q9NY98
• G1SYN

Gene Name

• SNTG1

Ensembl ID

• ENST00000517473
• ENSP00000431123
• ENSG00000147481
• ENST00000518864
• ENSP00000429276
• ENST00000522124
• ENSP00000429842
• ENST00000642720
• ENSP00000493900

Symbol

• SYN4
• G1SYN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.81
trait	0.75
protein domain	0.73
cell line	0.72
metabolite	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.35   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 105   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.35   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (75)

Explore Interacting Targets

1 – 10 of 75

• See Interactions on String-DB

DMD

Tclin

Novelty:  0.00025661

p_int:  0.999999999

p_ni:  1e-9

Score:  0.958

Data Source:  BioPlex,STRINGDB

DTNA

Tbio

Novelty:  0.01165754

p_int:  0.999999988

p_ni:  1.2e-8

Score:  0.841

Data Source:  BioPlex,STRINGDB

SNTB1

Tbio

Novelty:  0.05324344

p_int:  0.999999983

p_ni:  1.7e-8

Score:  0.821

Data Source:  BioPlex,STRINGDB

SNTA1

Tbio

Novelty:  0.01668288

p_int:  0.999999982

p_ni:  1.8e-8

Score:  0.817

Data Source:  BioPlex,STRINGDB

CTNNAL1

Tbio

Novelty:  0.03667606

p_int:  0.999999955

p_ni:  4.5e-8

Data Source:  BioPlex

DTNB

Tbio

Novelty:  0.0586565

p_int:  0.999999845

p_ni:  1.55e-7

Score:  0.885

Data Source:  BioPlex,STRINGDB

SNTB2

Tbio

Novelty:  0.05469501

p_int:  0.999998904

p_ni:  0.000001096

Score:  0.823

Data Source:  BioPlex,STRINGDB

MLYCD

Tchem

Family:  Enzyme

Novelty:  0.01670441

p_int:  0.999997131

p_ni:  0.000002869

Data Source:  BioPlex

LRRC4B

Tbio

Novelty:  0.21762254

p_int:  0.999564645

p_ni:  0.000361618

p_wrong:  0.000073737

Score:  0.17

Data Source:  BioPlex,STRINGDB

UTRN

Tchem

Novelty:  0.0018541

p_int:  0.999180186

p_ni:  0.00012629

p_wrong:  0.000693525

Score:  0.775

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (3)

Components (6)

Processes (1)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
protein C-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB
actin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
structural molecule activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age at first sexual intercourse measurement	EFO_0009749	1	1	1		48.5
smoking status measurement	EFO_0006527	1	1	1		35

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

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1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age at first sexual intercourse measurement	EFO_0009749	1		48.5
smoking status measurement	EFO_0006527	1		35

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Actin-binding
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
Nucleus
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
age at first sexual intercourse measurement
smoking status measurement

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	syntrophin gamma 1	VGNC:14594	464170
Macaque	syntrophin gamma 1		709244
Mouse	syntrophin, gamma 1	MGI:1918346	71096
Rat	syntrophin, gamma 1	RGD:1560290	500394
Dog	syntrophin gamma 1	VGNC:46615	486943

Species	Name	OMA	EggNOG	Inparanoid
Chimp	syntrophin gamma 1
Macaque	syntrophin gamma 1
Mouse	syntrophin, gamma 1
Rat	syntrophin, gamma 1
Dog	syntrophin gamma 1

Publication Statistics

PubMed Score 19.35

PubMed score by year

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PubTator Score 21.65

PubTator score by year

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Related Publications

Text Mined References (27)

GeneRif Annotations (6)

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10

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PMID	Year	Title