Protein Summary
Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation. The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This family member plays a role in mediating gamma-enolase trafficking to the plasma membrane and in enhancing its neurotrophic activity. Mutations in this gene are associated with idiopathic scoliosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
- ENST00000517473
- ENSP00000431123
- ENSG00000147481
- ENST00000518864
- ENSP00000429276
- ENST00000522124
- ENSP00000429842
- ENST00000642720
- ENSP00000493900
- SYN4
- G1SYN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.81 | ||
trait | 0.75 | ||
protein domain | 0.73 | ||
cell line | 0.72 | ||
metabolite | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.75 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 105 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.75 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 105 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (75)
DMD
Novelty: 0.00025661
p_int: 0.999999999
p_ni: 1e-9
Score: 0.958
Data Source: BioPlex,STRINGDB
DTNA
Novelty: 0.01165754
p_int: 0.999999988
p_ni: 1.2e-8
Score: 0.841
Data Source: BioPlex,STRINGDB
SNTB1
Novelty: 0.05324344
p_int: 0.999999983
p_ni: 1.7e-8
Score: 0.821
Data Source: BioPlex,STRINGDB
SNTA1
Novelty: 0.01668288
p_int: 0.999999982
p_ni: 1.8e-8
Score: 0.817
Data Source: BioPlex,STRINGDB
DTNB
Novelty: 0.0586565
p_int: 0.999999845
p_ni: 1.55e-7
Score: 0.885
Data Source: BioPlex,STRINGDB
SNTB2
Novelty: 0.05469501
p_int: 0.999998904
p_ni: 0.000001096
Score: 0.823
Data Source: BioPlex,STRINGDB
MLYCD
Family: Enzyme
Novelty: 0.01670441
p_int: 0.999997131
p_ni: 0.000002869
Data Source: BioPlex
LRRC4B
Novelty: 0.21762254
p_int: 0.999564645
p_ni: 0.000361618
p_wrong: 0.000073737
Score: 0.17
Data Source: BioPlex,STRINGDB
UTRN
Novelty: 0.0018541
p_int: 0.999180186
p_ni: 0.00012629
p_wrong: 0.000693525
Score: 0.775
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (3)
Components (6)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 1 | 72.5 | ||||||
substance abuse | 1 | 1 | 1 | 72.5 | |||||
antisocial behaviour measurement | 1 | 1 | 1 | 72.5 | |||||
systolic blood pressure | 1 | 1 | 1 | 51.6 | |||||
age at first sexual intercourse measurement | 1 | 1 | 1 | 37.7 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 72.5 | ||||||
substance abuse | 1 | 72.5 | |||||
antisocial behaviour measurement | 1 | 72.5 | |||||
systolic blood pressure | 1 | 51.6 | |||||
age at first sexual intercourse measurement | 1 | 37.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | syntrophin gamma 1 | VGNC:14594 | 464170 | |||||
Macaque | syntrophin gamma 1 | 709244 | ||||||
Mouse | MGI:1918346 | 71096 | ||||||
Rat | RGD:1560290 | 500394 | ||||||
Dog | syntrophin gamma 1 | VGNC:46615 | 486943 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | syntrophin gamma 1 | |||||
Macaque | syntrophin gamma 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | syntrophin gamma 1 | |||||
Publication Statistics
PubMed Score 65.75
PubMed score by year
PubTator Score 21.65
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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