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Tbio
SNTB2
Beta-2-syntrophin

Protein Summary
Description
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336278
  • ENSP00000338191
  • ENSG00000168807
  • ENST00000467311
  • ENSP00000436443
  • ENST00000562438
  • ENSP00000458999
  • ENSG00000260873

Symbol
  • D16S2531E
  • SNT2B2
  • SNTL
  • SNT3
  • SNTL
  • SNT2B2
  • EST25263
  • D16S2531E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
disease perturbation
0.9
transcription factor binding site profile
0.84
ligand (protein) perturbation
0.83
microRNA
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.26   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.26   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
SNTG2
Tbio
Novelty:  0.04056715
p_int:  0.999999914
p_ni:  8.5e-8
p_wrong:  1e-9
Score:  0.94
Data Source:  BioPlex,STRINGDB
DMD
Tclin
Novelty:  0.00025661
p_int:  0.999999746
p_ni:  2.51e-7
p_wrong:  3e-9
Score:  0.962
Data Source:  BioPlex,STRINGDB
SNTG1
Tbio
Novelty:  0.05608114
p_int:  0.999998904
p_ni:  0.000001096
Score:  0.823
Data Source:  BioPlex,STRINGDB
DTNB
Tbio
Novelty:  0.0586565
p_int:  0.999997981
p_ni:  0.000002019
Score:  0.718
Data Source:  BioPlex,STRINGDB
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.999894827
p_ni:  0.000105144
p_wrong:  2.9e-8
Data Source:  BioPlex
RHPN1
Tbio
Novelty:  0.05722992
p_int:  0.999810703
p_ni:  0.000189297
Data Source:  BioPlex
HMG20A
Tbio
Family:  TF
Novelty:  0.11994252
p_int:  0.999794894
p_ni:  0.000205105
p_wrong:  1e-9
Data Source:  BioPlex
TAGAP
Tbio
Family:  Enzyme
Novelty:  0.04450409
p_int:  0.999655526
p_ni:  0.000344474
Data Source:  BioPlex
CPNE5
Tbio
Novelty:  0.09416684
p_int:  0.999653775
p_ni:  0.000346224
p_wrong:  1e-9
Data Source:  BioPlex
CFAP36
Tdark
Novelty:  0.42842118
p_int:  0.9959379
p_ni:  0.004062095
p_wrong:  5e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
2
4
80.6
daytime rest measurement
1
1
1
55.2
body mass index
1
1
1
42.3
telomere length
1
1
1
38.8
apolipoprotein A 1 measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
80.6
daytime rest measurement
1
55.2
body mass index
1
42.3
telomere length
1
38.8
apolipoprotein A 1 measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:101771
20650
Rat
RGD:1592340
689421
Dog
syntrophin beta 2
VGNC:46614
479675
Horse
syntrophin beta 2
VGNC:23404
100066988
Cow
syntrophin beta 2
VGNC:35084
786534
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
syntrophin beta 2
Horse
syntrophin beta 2
Cow
syntrophin beta 2
Publication Statistics
PubMed Score 18.26
PubMed score by year
PubTator Score 9.07
PubTator score by year
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Related Publications
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PMID
Year
Title