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Tdark
SNRPF
Small nuclear ribonucleoprotein F

Protein Summary
Description
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266735
  • ENSP00000266735
  • ENSG00000139343

Symbol
  • PBSCF
  • SMF
  • Sm-F
  • snRNP-F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
kinase perturbation
0.84
transcription factor perturbation
0.84
histone modification site profile
0.82
protein complex
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.91   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.91   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (527)
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.999999986
p_ni:  1e-9
p_wrong:  1.3e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
BPIFA2
Tbio
Novelty:  0.01533858
p_int:  0.999998569
p_ni:  0.000001431
Data Source:  BioPlex
LSM10
Tbio
Novelty:  0.16403413
p_int:  0.999998541
p_ni:  0.000001294
p_wrong:  1.65e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
CMTR2
Tbio
Family:  Enzyme
Novelty:  0.11208282
p_int:  0.999994232
p_ni:  0.000004072
p_wrong:  0.000001696
Score:  0.564
Data Source:  BioPlex,STRINGDB
PDCD7
Tbio
Novelty:  0.15531712
p_int:  0.999992103
p_ni:  0.000007892
p_wrong:  5e-9
Score:  0.953
Data Source:  BioPlex,STRINGDB
SNRNP48
Tbio
Novelty:  0.16395917
p_int:  0.999985684
p_ni:  0.000014316
Score:  0.952
Data Source:  BioPlex,STRINGDB
ZMAT5
Tdark
Novelty:  0.97115324
p_int:  0.999984245
p_ni:  0.000015755
Score:  0.992
Data Source:  BioPlex,STRINGDB
SNRNP35
Tdark
Novelty:  1.00002211
p_int:  0.999983361
p_ni:  0.000002318
p_wrong:  0.000014321
Score:  0.987
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999980494
p_ni:  0.000019506
Score:  0.999
Data Source:  BioPlex,STRINGDB
GPBP1L1
Tdark
Novelty:  0.69320833
p_int:  0.999960619
p_ni:  0.000039381
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Gene expression (Transcription) (R-HSA-74160)

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Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Metabolism of non-coding RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
6
7
10
99.1
vitamin D deficiency
1
1
1
80.9
serum metabolite measurement
2
1
2
69.3
blood metabolite measurement
1
1
1
62.8
amino acid measurement
1
1
1
62.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
10
99.1
vitamin D deficiency
1
80.9
serum metabolite measurement
2
69.3
blood metabolite measurement
1
62.8
amino acid measurement
1
62.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
small nuclear ribonucleoprotein polypeptide F
716917
Mouse
MGI:1917128
69878
Rat
RGD:1588229
680737
Horse
small nuclear ribonucleoprotein polypeptide F
VGNC:23401
100630068
Cow
small nuclear ribonucleoprotein polypeptide F
VGNC:35081
615240
Species
Name
OMA
EggNOG
Inparanoid
Macaque
small nuclear ribonucleoprotein polypeptide F
Mouse
Rat
Horse
small nuclear ribonucleoprotein polypeptide F
Cow
small nuclear ribonucleoprotein polypeptide F
Publication Statistics
PubMed Score 4.91
PubMed score by year
PubTator Score 20.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title