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Tbio
SNRPE
Small nuclear ribonucleoprotein E

Protein Summary
Description
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:23246290, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319). May indirectly play a role in hair development (PubMed:23246290). The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000414487
  • ENSP00000400591
  • ENSG00000182004

Symbol
  • SME
  • Sm-E
  • HYPT11
  • snRNP-E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
transcription factor binding site profile
0.97
protein complex
0.93
histone modification site profile
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.95   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.95   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (515)
SNRPN
Tbio
Novelty:  0.002157
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
SF3A2
Tbio
Novelty:  0.03658692
p_int:  0.999999389
p_ni:  6.11e-7
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
CMTR2
Tbio
Family:  Enzyme
Novelty:  0.11208282
p_int:  0.999998225
p_ni:  0.000001768
p_wrong:  7e-9
Score:  0.64
Data Source:  BioPlex,STRINGDB
TUT1
Tbio
Family:  Enzyme
Novelty:  0.01436913
p_int:  0.999994905
p_ni:  0.000005095
Score:  0.713
Data Source:  BioPlex,STRINGDB
SLC4A1AP
Tdark
Family:  Transporter
Novelty:  0.41125302
p_int:  0.999991627
p_ni:  0.000008367
p_wrong:  6e-9
Score:  0.359
Data Source:  BioPlex,STRINGDB
CWF19L2
Tdark
Novelty:  0.80210985
p_int:  0.999989654
p_ni:  0.000010346
Score:  0.816
Data Source:  BioPlex,STRINGDB
ZRSR2
Tbio
Novelty:  0.03449891
p_int:  0.999989493
p_ni:  0.000010507
Score:  0.951
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.999987291
p_ni:  0.000011623
p_wrong:  0.000001088
Data Source:  BioPlex
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.999980494
p_ni:  0.000019506
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRNP35
Tdark
Novelty:  1.00002211
p_int:  0.999972994
p_ni:  0.000023277
p_wrong:  0.000003729
Score:  0.993
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Metabolism of non-coding RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
85.2
1
2
2
71.4
1
1
0
1.1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
85.2
2
71.4
0
1.1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
small nuclear ribonucleoprotein polypeptide E
701418
Mouse
MGI:98346
20643
Rat
RGD:2321675
100360682
Pig
small nuclear ribonucleoprotein polypeptide E
100038330
Opossum
small nuclear ribonucleoprotein polypeptide E
100012867
Species
Name
OMA
EggNOG
Inparanoid
Macaque
small nuclear ribonucleoprotein polypeptide E
Mouse
Rat
Pig
small nuclear ribonucleoprotein polypeptide E
Opossum
small nuclear ribonucleoprotein polypeptide E
Publication Statistics
PubMed Score 47.95
PubMed score by year
PubTator Score 28.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title