Tbio SNRPD2 Small nuclear ribonucleoprotein Sm D2

Protein Summary

Description

Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Uniprot Accession IDs

• P62316
• A8K797
• J3KPM5
• P43330
• Sm-D2

Gene Name

• SNRPD2

Ensembl ID

• ENST00000342669
• ENSP00000342374
• ENSG00000125743
• ENST00000391932
• ENSP00000375798
• ENST00000587367
• ENSP00000465952
• ENST00000588301
• ENSP00000465216
• ENST00000588599
• ENSP00000466152

Symbol

• SNRPD1
• SMD2
• Sm-D2
• SNRPD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
disease perturbation	0.97
kinase perturbation	0.95
histone modification site profile	0.93
protein complex	0.84

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Small Nuclear Ribonucleoprotein Sm D2

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Small Nuclear Ribonucleoprotein Sm D2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.99   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 185   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.99   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0