Tbio SNRPD2 Small nuclear ribonucleoprotein Sm D2

Protein Summary

Description

Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Uniprot Accession IDs

• P62316
• A8K797
• J3KPM5
• P43330
• Sm-D2

Gene Name

• SNRPD2

Ensembl ID

• ENST00000342669
• ENSP00000342374
• ENSG00000125743
• ENST00000391932
• ENSP00000375798
• ENST00000587367
• ENSP00000465952
• ENST00000588301
• ENSP00000465216
• ENST00000588599
• ENSP00000466152

Symbol

• SNRPD1
• SMD2
• Sm-D2
• SNRPD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
disease perturbation	0.97
kinase perturbation	0.95
histone modification site profile	0.93
protein complex	0.84

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Small Nuclear Ribonucleoprotein Sm D2

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Small Nuclear Ribonucleoprotein Sm D2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.12   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 185   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.12   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (518)

Explore Interacting Targets

1 – 10 of 518

• See Interactions on String-DB

SNRPN

Tbio

Novelty:  0.002157

p_int:  0.999952931

p_ni:  0.000047069

Score:  0.997

Data Source:  BioPlex,STRINGDB

SNRPF

Tdark

Novelty:  0.17624854

p_int:  0.999821877

p_ni:  0.000178123

Score:  0.999

Data Source:  BioPlex,STRINGDB

SNRNP70

Tbio

Novelty:  0.00116631

p_int:  0.999672926

p_ni:  0.000327074

Score:  0.999

Data Source:  BioPlex,STRINGDB

SNRPGP15

Tdark

p_int:  0.999428515

p_ni:  0.000571485

Data Source:  BioPlex

SNRPE

Tbio

Novelty:  0.02033423

p_int:  0.994752851

p_ni:  0.005247149

Score:  0.999

Data Source:  BioPlex,STRINGDB

SNRPC

Tbio

Novelty:  0.02049921

p_int:  0.99408594

p_ni:  0.00591406

Score:  0.999

Data Source:  BioPlex,STRINGDB

SNRPB

Tbio

Novelty:  0.01503535

p_int:  0.993062926

p_ni:  0.006937074

Score:  0.999

Data Source:  BioPlex,STRINGDB

CD2BP2

Tbio

Novelty:  0.01440995

p_int:  0.991674952

p_ni:  0.008325048

Score:  0.985

Data Source:  BioPlex,STRINGDB

SNRPA1

Tbio

Novelty:  0.01232044

p_int:  0.982684232

p_ni:  0.017315768

Score:  0.999

Data Source:  BioPlex,STRINGDB

DDX23

Tbio

Family:  Enzyme

Novelty:  0.03592096

p_int:  0.95917903

p_ni:  0.04082097

Score:  0.999

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (7)

KEGG (1)

PathwayCommons (1)

WikiPathways (1)

Metabolism of RNA (R-HSA-8953854)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Metabolism of non-coding RNA	53 targets	R-HSA-194441
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	mRNA Splicing	188 targets	R-HSA-72172
Reactome	mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
Metabolism of non-coding RNA	53 targets	R-HSA-194441
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
mRNA Splicing	188 targets	R-HSA-72172
mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (24)

Functions (1)

Components (18)

Processes (5)

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GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (44)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 44

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	17	6	23	4.2	98.2
type II diabetes mellitus	EFO_0001360	9	8	4	1.1	97.2
low density lipoprotein cholesterol measurement	EFO_0004611	2	4	5		96.5
apolipoprotein B measurement	EFO_0004615	2	3	4		94.9
total cholesterol measurement	EFO_0004574	1	3	3		92.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	23	4.2	98.2
type II diabetes mellitus	EFO_0001360	4	1.1	97.2
low density lipoprotein cholesterol measurement	EFO_0004611	5		96.5
apolipoprotein B measurement	EFO_0004615	4		94.9
total cholesterol measurement	EFO_0004574	3		92.4

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Isopeptide bond
mRNA processing
mRNA splicing
Nucleus

GWAS Trait Find Similar Targets

No Header	No Header
Alzheimer's disease
anthropometric measurement
apolipoprotein B measurement
blood urea nitrogen measurement
BMI-adjusted hip circumference
body fat percentage
body height
body mass index
C-reactive protein measurement
chronic obstructive pulmonary disease

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	small nuclear ribonucleoprotein D2 polypeptide	VGNC:2423	456134
Macaque	small nuclear ribonucleoprotein D2 polypeptide		715183
Mouse	small nuclear ribonucleoprotein D2	MGI:98345	107686
Rat	small nuclear ribonucleoprotein D2 polypeptide	RGD:1593018	680309
Dog	small nuclear ribonucleoprotein D2 polypeptide	VGNC:53987	100685983

Species	Name	OMA	EggNOG	Inparanoid
Chimp	small nuclear ribonucleoprotein D2 polypeptide
Macaque	small nuclear ribonucleoprotein D2 polypeptide
Mouse	small nuclear ribonucleoprotein D2
Rat	small nuclear ribonucleoprotein D2 polypeptide
Dog	small nuclear ribonucleoprotein D2 polypeptide

Publication Statistics

PubMed Score 39.12

PubMed score by year

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PubTator Score 34.38

PubTator score by year

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Related Publications

Text Mined References (48)

GeneRif Annotations (1)

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0 of 0

PMID	Year	Title