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Tbio
SNRPD1
Small nuclear ribonucleoprotein Sm D1

Protein Summary
Description
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (Probable). This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300413
  • ENSP00000300413
  • ENSG00000167088

Symbol
  • SMD1
  • SNRPD
  • Sm-D1
  • HsT2456
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
hub protein
0.85
gene perturbation
0.83
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.17   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.17   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (424)
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.9999685
p_ni:  0.0000315
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.999882723
p_ni:  0.000117277
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.999791125
p_ni:  0.000208871
p_wrong:  4e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.999551851
p_ni:  0.000448143
p_wrong:  6e-9
Data Source:  BioPlex
SNRPC
Tbio
Novelty:  0.02049921
p_int:  0.998667347
p_ni:  0.001332653
Score:  0.998
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.998600811
p_ni:  0.001399188
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.998575967
p_ni:  0.001424032
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
CD2BP2
Tbio
Novelty:  0.01440995
p_int:  0.997840451
p_ni:  0.00215954
p_wrong:  9e-9
Score:  0.985
Data Source:  BioPlex,STRINGDB
LSM6
Tbio
Novelty:  0.09507671
p_int:  0.969684388
p_ni:  0.03031561
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
LSM3
Tbio
Novelty:  0.05044984
p_int:  0.957608327
p_ni:  0.042391673
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Metabolism of RNA (R-HSA-8953854)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of non-coding RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
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Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein D1 polypeptide
VGNC:13289
455329
Macaque
small nuclear ribonucleoprotein D1 polypeptide
698965
Mouse
MGI:98344
20641
Rat
RGD:1306345
291794
Dog
small nuclear ribonucleoprotein D1 polypeptide
VGNC:46611
480178
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein D1 polypeptide
Macaque
small nuclear ribonucleoprotein D1 polypeptide
Mouse
Rat
Dog
small nuclear ribonucleoprotein D1 polypeptide
Publication Statistics
PubMed Score 67.17
PubMed score by year
PubTator Score 113.78
PubTator score by year
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Related Publications
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PMID
Year
Title