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Tbio
SNRPC
U1 small nuclear ribonucleoprotein C

Protein Summary
Description
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing result ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244520
  • ENSP00000244520
  • ENSG00000124562

Symbol
  • U1C
  • Yhc1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor binding site profile
0.89
hub protein
0.85
histone modification site profile
0.82
molecular function
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.72   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.72   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (294)
CMTR2
Tbio
Family:  Enzyme
Novelty:  0.11208282
p_int:  0.999999252
p_ni:  7.47e-7
p_wrong:  1e-9
Data Source:  BioPlex
NIN
Tbio
Novelty:  0.01312714
p_int:  0.999992059
p_ni:  0.000007941
Data Source:  BioPlex
SNRPA
Tbio
Novelty:  0.00184221
p_int:  0.99952043
p_ni:  0.00047957
Score:  0.998
Data Source:  BioPlex,STRINGDB
WBP11
Tbio
Novelty:  0.03891455
p_int:  0.999449851
p_ni:  0.000545114
p_wrong:  0.000005035
Score:  0.931
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.998791291
p_ni:  0.001208709
Score:  0.998
Data Source:  BioPlex,STRINGDB
SNRPD1
Tbio
Novelty:  0.0136355
p_int:  0.998667347
p_ni:  0.001332653
Score:  0.998
Data Source:  BioPlex,STRINGDB
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
p_int:  0.998604326
p_ni:  0.001386505
p_wrong:  0.000009169
Score:  0.284
Data Source:  BioPlex,STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.99542502
p_ni:  0.00457498
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPD2
Tbio
Novelty:  0.02519503
p_int:  0.99408594
p_ni:  0.00591406
Score:  0.999
Data Source:  BioPlex,STRINGDB
GNPAT
Tchem
Family:  Enzyme
Novelty:  0.01255689
p_int:  0.993107418
p_ni:  0.006892563
p_wrong:  1.9e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
7
10
97.1
body mass index
5
5
6
96.2
BMI-adjusted waist-hip ratio
2
4
4
90.1
waist-hip ratio
1
3
3
88.7
red blood cell distribution width
2
2
2
88.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
10
97.1
body mass index
6
96.2
BMI-adjusted waist-hip ratio
4
90.1
waist-hip ratio
3
88.7
red blood cell distribution width
2
88.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein polypeptide C
VGNC:11300
747404
Macaque
small nuclear ribonucleoprotein polypeptide C
718654
Mouse
MGI:109489
20630
Rat
RGD:1306065
361808
Horse
small nuclear ribonucleoprotein polypeptide C
VGNC:23397
100053207
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein polypeptide C
Macaque
small nuclear ribonucleoprotein polypeptide C
Mouse
Rat
Horse
small nuclear ribonucleoprotein polypeptide C
Publication Statistics
PubMed Score 50.72
PubMed score by year
PubTator Score 20.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title