Tbio SNRPA1 U2 small nuclear ribonucleoprotein A'

Protein Summary

Description

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:27035939). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128, PubMed:27035939).

Uniprot Accession IDs

• P09661
• B2R5I6
• Q8TBD2
• U2 snRNP A'

Gene Name

• SNRPA1

Ensembl ID

• ENST00000254193
• ENSP00000254193
• ENSG00000131876

Symbol

• Lea1
• U2A'

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
co-expressed gene	0.87
kinase perturbation	0.84
interacting protein	0.82
protein complex	0.81

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / U2 Small Nuclear Ribonucleoprotein A'

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / U2 Small Nuclear Ribonucleoprotein A'

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.03   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.03   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0