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Tbio
SNRPA1
U2 small nuclear ribonucleoprotein A'

Protein Summary
Description
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:27035939). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128, PubMed:27035939).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254193
  • ENSP00000254193
  • ENSG00000131876

Symbol
  • Lea1
  • U2A'
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
co-expressed gene
0.87
kinase perturbation
0.84
interacting protein
0.82
protein complex
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.42   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.42   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (363)
SNRPN
Tbio
Novelty:  0.002157
p_int:  1
Score:  0.995
Data Source:  BioPlex,STRINGDB
PRKRIP1
Tdark
Novelty:  0.24236931
p_int:  0.999999919
p_ni:  6.9e-8
p_wrong:  1.2e-8
Score:  0.95
Data Source:  BioPlex,STRINGDB
SLC4A1AP
Tdark
Family:  Transporter
Novelty:  0.41125302
p_int:  0.999992998
p_ni:  0.000007002
Score:  0.592
Data Source:  BioPlex,STRINGDB
GEMIN5
Tbio
Novelty:  0.03683801
p_int:  0.99999161
p_ni:  0.00000839
Score:  0.766
Data Source:  BioPlex,STRINGDB
TGS1
Tbio
Family:  Enzyme
Novelty:  0.03390504
p_int:  0.999989625
p_ni:  0.000010375
Score:  0.869
Data Source:  BioPlex,STRINGDB
TOE1
Tbio
Novelty:  0.03660884
p_int:  0.999982794
p_ni:  0.000017206
Score:  0.768
Data Source:  BioPlex,STRINGDB
GPATCH11
Tdark
Novelty:  0.86338046
p_int:  0.999934016
p_ni:  0.000065983
Score:  0.628
Data Source:  BioPlex,STRINGDB
SF3A2
Tbio
Novelty:  0.03658692
p_int:  0.999925531
p_ni:  0.000061292
p_wrong:  0.000013176
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPB2
Tbio
Novelty:  0.17219587
p_int:  0.99991566
p_ni:  0.00008434
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNUPN
Tbio
Novelty:  0.04456914
p_int:  0.999909791
p_ni:  0.000090209
Score:  0.744
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-12 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Immune System
Interleukin-12 family signaling
Interleukin-12 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
2
3
92.3
neutrophil percentage of leukocytes
2
2
2
88.8
basophil count
2
2
2
79.2
lymphocyte percentage of leukocytes
1
1
1
67.4
triglyceride measurement
2
2
2
59.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
92.3
neutrophil percentage of leukocytes
2
88.8
basophil count
2
79.2
lymphocyte percentage of leukocytes
1
67.4
triglyceride measurement
2
59.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein polypeptide A'
453692
Macaque
small nuclear ribonucleoprotein polypeptide A'
694876
Mouse
MGI:1916231
68981
Rat
RGD:2320494
100361269
Dog
small nuclear ribonucleoprotein polypeptide A'
VGNC:46610
607102
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein polypeptide A'
Macaque
small nuclear ribonucleoprotein polypeptide A'
Mouse
Rat
Dog
small nuclear ribonucleoprotein polypeptide A'
Publication Statistics
PubMed Score 78.42
PubMed score by year
PubTator Score 9.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title