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Tbio
SNRNP40
U5 small nuclear ribonucleoprotein 40 kDa protein

Protein Summary
Description
Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs. This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263694
  • ENSP00000263694
  • ENSG00000060688

Symbol
  • PRP8BP
  • SFP38
  • WDR57
  • 40K
  • SPF38
  • WDR57
  • PRP8BP
  • HPRP8BP
  • PRPF8BP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
disease perturbation
0.9
histone modification site profile
0.9
kinase perturbation
0.76
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.68   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.68   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (290)
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.999976217
p_ni:  0.000023783
Score:  0.858
Data Source:  BioPlex,STRINGDB
CD2BP2
Tbio
Novelty:  0.01440995
p_int:  0.999951946
p_ni:  0.000048054
Score:  0.988
Data Source:  BioPlex,STRINGDB
RSRC1
Tbio
Novelty:  0.12148079
p_int:  0.99986171
p_ni:  0.00013829
Score:  0.789
Data Source:  BioPlex,STRINGDB
PAXBP1
Tbio
Novelty:  0.13631396
p_int:  0.999831471
p_ni:  0.000168529
Score:  0.801
Data Source:  BioPlex,STRINGDB
TFIP11
Tbio
Novelty:  0.01546496
p_int:  0.999572155
p_ni:  0.000427845
Score:  0.976
Data Source:  BioPlex,STRINGDB
DDX23
Tbio
Family:  Enzyme
Novelty:  0.03592096
p_int:  0.999320314
p_ni:  0.000679686
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.999270732
p_ni:  0.000729268
Score:  0.963
Data Source:  BioPlex,STRINGDB
DHX38
Tbio
Family:  Enzyme
Novelty:  0.01939445
p_int:  0.999118796
p_ni:  0.000881201
p_wrong:  3e-9
Score:  0.935
Data Source:  BioPlex,STRINGDB
ECD
Tbio
Novelty:  0.06070487
p_int:  0.997842416
p_ni:  0.002157584
Score:  0.737
Data Source:  BioPlex,STRINGDB
SNRNP200
Tchem
Family:  Enzyme
Novelty:  0.01339666
p_int:  0.997244947
p_ni:  0.002755053
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Reactome
mRNA Splicing - Minor Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
1
1
1
55.2
BMI-adjusted hip circumference
1
1
1
46.9
serum urea measurement
1
1
1
31.4
hematocrit
1
1
1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
1
55.2
BMI-adjusted hip circumference
1
46.9
serum urea measurement
1
31.4
hematocrit
1
3.4
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein U5 subunit 40
VGNC:8559
470976
Macaque
small nuclear ribonucleoprotein U5 subunit 40
705059
Mouse
MGI:1913835
66585
Rat
RGD:1309198
313056
Dog
small nuclear ribonucleoprotein U5 subunit 40
VGNC:46607
611914
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein U5 subunit 40
Macaque
small nuclear ribonucleoprotein U5 subunit 40
Mouse
Rat
Dog
small nuclear ribonucleoprotein U5 subunit 40
Publication Statistics
PubMed Score 5.68
PubMed score by year
PubTator Score 104.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title